January 10, 2020 10 min read

If you're looking for an extreme pre-workout designed to deliver incredible energy, enhanced focus, and explosive workouts, AMPED-AF is exactly what you're looking for...

Make no mistake AMPED-AF is not for beginners...

That's why it's recommended to start with a 1/4 of a scoop your first time trying it.

Now let's get into the details...

Why chooseAMPED AF?

Because it's backed by science to help optimize:

• EXTREME ENERGY*

• LASTING ENDURANCE*

• EXPLOSIVE POWER

• INTENSE FOCUS*

• STRENGTH*

• NO CRASH*

• ENHANCE VASOLIDATON*

• REDUCES FATIGUE*

Here's a detailed list of all the ingredients used in AMPED-AF:

 

Vitamin B6:Vitamin B6, also known as pyridoxine, is a water-soluble vitamin that your body needs for several functions. 

It’s significant to protein, fat and carbohydrate metabolism and the creation of red blood cells and neurotransmitters. 

Your body cannot produce vitamin B6, so you must obtain it from foods or supplements. 

Consuming adequate amounts of vitamin B6 is important for optimal health and may even prevent and treat chronic diseases. 

Here are 9 health benefits of vitamin B6:

  1. May improve mood and reduce symptoms of depression
  2. May promote brain health and reduce Alzheimer’s risk
  3. May prevent and treat anemia by aiding hemoglobin production
  4. May be useful in treating symptoms of PMS
  5. May help treat nausea during pregnancy
  6. May prevent clogged arteries and reduce heart disease risk
  7. May help prevent cancer
  8. May promote eye health and prevent eye diseases
  9. May treat inflammation associated with Rheumatoid arthritis

References:

  • National Institutes of Health: Office of Dietary Supplements
  • Molecules. 2010 Jan 20;15(1):442-59
  • Psychother Psychosom 2004 Nov-Dec;73(6): 340-3

 

Vitamin B12: Vitamin B12, also known as cobalamin, is an essential vitamin that your body needs but cannot produce. 

It’s found naturally in animal products but also added to certain foods and available as an oral supplement or injection. 

Vitamin B12 has many roles in your body. It supports the normal function of your nerve cells and is needed for red blood cell formation and DNA synthesis. Vitamin B12 may benefit your body in impressive ways, such as by boosting your energy, improving your memory and helping prevent heart disease.

Here are 9 health benefits of vitamin B12:

  1. Helps with red blood cell formation and Anemia prevention
  2. May prevent major birth defects
  3. May support bone health and prevent osteoporosis
  4. May reduce your risk of macular degeneration
  5. May improve mood and symptoms of depression
  6. May benefit your brain by preventing the loss of neurons
  7. May give you an energy boost
  8. May improve heart health by decreasing homocysteine
  9. Supports healthy hair, skin, and nails

References:

  • Food Nutr Bull. 2008 June; 29(2 Suppl): S101-11; discussion S112-5
  • Arch Gynecol Obstet. 2009 Sep;280(3):381-7
  • Arch Intern Med. 2009 Feb 23; 169(4): 335–341.

 

L-Citrulline: L-Citrulline is an amino acid that is turned into L-arginine in the kidneys after supplementation, which means L-citrulline supplementation is a more effective method of increasing L-arginine levels in the body than L-arginine supplementation itself. 

Taking L-Citrulline increases plasma levels of ornithine and arginine and improves the ammonia recycling process and nitric oxide metabolism.

Consequently, it is used in areas where nitric oxide is relevant, namely erectile dysfunction caused by high blood pressure, athletic performance, and cardiovascular health.There are very few foods that have notable amounts of citrulline. 

Benefits to your health from L-Citrulline include:

  • Help your blood vessels widen
  • May reduce blood pressure
  • Can increase rise in growth hormone (GH) after exercise

References:

  • Eur J Appl Physiol. 2010 Sep;110(2):341-51
  • Cardiol J. 2010;17(6):612-8
  • Immunol Endocr Metab Agents Med Chem. 2013 Sep;13(3):214-220.

Beta Alanine: Beta-alanine is a non-essential amino acid, and unlike most amino acids, it is not used by your body to synthesize proteins. Instead, together with histidine, it produces carnosine.

Carnosine is then stored in your skeletal muscles and reduces lactic acid accumulation in your muscles during exercise, which leads to improved athletic performance. 

In your muscles, histidine levels are normally high and beta-alanine levels low, which limits the production of carnosine. Supplementing with beta-alanine has been shown to elevate carnosine levels in muscles by 80%.

This is how carnosine acts during exercise:

  • Glucose is broken down. This process called glycolysis. and it is the main source of fuel during high-intensity exercise.
  • Lactate is produced: As you exercise, your muscles break glucose down into lactic acid. This is converted into lactate, which produces hydrogen ions (H+).
  • Muscles become more acidic: The hydrogen ions reduce the pH level in your muscles, making them more acidic.
  • Fatigue sets in: Muscle acidity blocks glucose breakdown and reduces your muscles' ability to contract. This causes fatigue.
  • Carnosine buffer: Carnosine serves as a buffer against the acid, reducing the acidity in muscles during high-intensity exercise.

Since beta-alanine supplements increase carnosine levels, they help reduce acid levels in your muscles during exercise, which lessens overall fatigue.

References:

  • J Appl Physiol (1985). 2007 Nov;103(5):1736-43
  • Amino Acids. 2012 Jul; 43(1): 25–37.

 

Betaine Anhydrous: Betaine anhydrous is a chemical that occurs naturally in the body and can also be found in foods such as beets, spinach, cereals, seafood, and wine.

A form of betaine called betaine anhydrous helps in the metabolism of homocysteine, a chemical involved in the normal function of many different parts of the body, including blood, bones, eyes, heart, nerves, and the brain.

Betaine anhydrous prevents the buildup of homocysteine seen in people who have problems with its metabolism from birth. Homocysteine is involved in the normal function of many different parts of the body, including blood, bones, eyes, heart, muscles, nerves, and the brain.

Betaine anhydrous prevents the buildup of homocysteine in the blood.

 

References

  • J Int Soc Sports Nutr. 2013; 10: 39.

 

AMPED-AF Energy and Focus Blend:

N-Acetyl L Tyrosine: Tyrosine is an amino acid that is naturally produced in the body from another amino acid called phenylalanine. 

Tyrosine is a popular dietary supplement used to improve alertness, attention, and focus. It produces important brain chemicals that help nerve cells communicate and may even regulate mood. It is also found in chicken, turkey, fish, dairy products and most other high-protein foods.

Tyrosine helps make several important substances, including:

  • Dopamine: Dopamine regulates your reward and pleasure centers. This important brain chemical is also important for memory and motor skills.
  • Adrenaline and noradrenaline: These hormones are responsible for the fight-or-flight response to stressful situations. They prepare the body to “fight” or “flee” from a perceived attack or harm.
  • Thyroid hormones: Thyroid hormones are produced by the thyroid gland and primarily responsible for regulating metabolism.
  • Melanin: This pigment gives your skin, hair, and eyes their color. Dark-skinned people have more melanin in their skin than light-skinned people.

Supplementing with tyrosine is thought to increase levels of the neurotransmitter’s dopamine, adrenaline, and norepinephrine. 

By increasing these neurotransmitters, it may help improve memory and performance in stressful situations. Studies show that tyrosine can help maintain your mental capacity when taken before a stressful activity.

References:

  • J Psychiatry Neurosci. 2007 May; 32(3): 224
  • J Nutr. 2007 Jun;137(6 Suppl 1):1539S-1547S
  • Physiol Rev. 2014 Apr; 94(2): 355–382.
  • Pigment Cell Melanoma Res. 2012 Jan;25(1):14-27



Caffeine anhydrous: Caffeine increases focus and mental stimulation. One of the main mechanisms is by increasing adrenaline. Adrenaline is a powerful stimulatory chemical, but not the only mechanism of caffeine.

The main mechanism that makes caffeine unique is adenosine activity (as a receptor antagonist), which essentially helps increase alertness and reduce feelings of lethargy. There are some studies to suggest caffeine has a positive effect on memory formation too. 

In addition; Caffeine and coffee have been shown to cause major improvements in performance for endurance athletes. For high-intensity sports like cycling or swimming, caffeine may benefit trained athletes but not untrained individuals. 

For strength or power-based exercises, the research about the effects of caffeine is mostly positive but still mixed. Caffeine can help release stored fat from fat cells, especially before and at the end of a workout. It can also help you burn more calories.

References:

  • J Alzheimers Dis. 2010;20 Suppl 1:S85-94
  • Br J Sports Med. 1992 Jun; 26(2): 116–120.
  • Int J Sport Nutr Exerc Metab. 2008 Aug;18(4):412-29
  • Med Sci Sports Exerc. 2010 Jul;42(7):1375-87
  • Am J Physiol. 1992 Jun;262(6 Pt 1):E891-8.

 

Senegalia berlandieri extract: Senegalia Berlandieri is a shrub native to the Southwestern United States and northeast Mexico that belongs to the subfamily Mimosoideae (wattles) of Fabaceae (legumes). 

S. berlandieri contains a number of diverse alkaloids, the most plentiful of which are N-methylphenethylamine, tyramine, and phenethylamine. The alkaloids from Senegalia Berlandieri are biologically similar to those found in ephedra and possess similar properties.

Senegalia alkaloids, like the ephedra alkaloids, readily pass cross the blood-brain barrier.

References:

  • B.A. Clement, C. M. Goff and T. D. A. Forbes (1997). "Toxic amines and alkaloids from Acacia berlandieri." Phytochemistry 46 249-254.

 

Beta Phenylethylamine (PEA): PEA is a hormone-like substance that occurs naturally in your brain and body. It functions as a neurotransmitter that gives you heightened focus, attention, goal-directed behavior, and task-completion. 

Combined with its mood-elevating effects, PEA can bring about an increased feeling of get-up-and-go, an enhanced sense of well-being, and optimal cognitive performance.

Moreover, PEA amplifies the actions of other key brain chemicals such as serotonin, dopamine, norepinephrine, and acetylcholine. As such, PEA is thought to slow down the rate at which your brain and body age, extend healthspan, and increase longevity.

Proper supplementation with PEA is designed to provide rapid improvements in mental clarity, mood, stamina, energy, libido, joy, and motivation.

References:

Proc Natl Acad Sci U S A. 1982 Oct;79(20):6385-

 

Hordenine: Hordenine, otherwise known as N, N-dimethyltyramine, is an alkaloid mainly found in plants such as barley that are used as feed for animals. 

It is adrenergic, meaning it causes nerve cells to release the neurotransmitters epinephrine (adrenaline) and norepinephrine (noradrenaline). Molecules like epinephrine and norepinephrine increase energy and focus and are part of the “fight-or-flight” response.

Health benefits of Hordenine:

  • May increase alertness:Hordenine has been shown to increase alertness within two minutes.
  • May increase energy: Hordenine increases response to noradrenaline, therefore causes increased energy and focus after consumption.

Figure: a: Reaction time: Average number of hits. * = Significant difference (p < 0.05) between the supplement and placebo. b: Reaction time: Average percentage of successful hits from total possible targets. * = Significant difference (p < 0.05) between the supplement and placebo. Data are reported mean ± SD

References:

  • Dtsch Tierarztl Wochenschr. 1995 Jun;102(6):228-32
  • Neurochem Res. 2012 Nov; 37(11): 2496–2512.
  • J Int Soc Sports Nutr. 2009; 6: 2

 

N methyl Tyramine, (arecoline hydrobromide 98%):N-Methyltyramine, also known as 4-hydroxy-N-methylphenethylamine, is a human trace amine and natural phenethylamine alkaloid found in a variety of plants.

It is the N-methyl analog of tyramine, which is a well-known biogenic trace amine with which NMT shares many pharmacological properties.

NMT supplementation is unquestionably effective for bodybuilding enthusiasts and athletes alike. 

N-methyltyramine is a neuromodulator, so the main advantages of NMT supplementation are cognitive changes, such as enhanced motivation, increased focus, and a greater sense of urgency.

Intuitively, the mental benefits of NMT translate to physical benefits as well, like better athletic performance, elevated thermogenesis (calorie expenditure), and thus, improved fat loss.

References:

  • Gainetdinov, R. R., Hoener, M. C., & Berry, M. D. (2018). Trace amines and their receptors. Pharmacological Reviews, 70(3), 549-620.
  • Yokoo, et al. (1999). Isolation from beer and structural determination of a potent stimulant of gastrin release. Alcohol and alcoholism (Oxford, Oxfordshire), 34(2), 161-168.

 

Cymbidium Goeringii Extract:  Cymbidium Goeringii Extract is also known as Orchilean and it's an adaptogenic herb derived from the Noble orchid, a flowering plant used in traditional medicine in China, Nepal, and Northern India.

In its natural form, Cymbidium Goeringii is a botanical tonic that can greatly improve the body’s ability to increase energy levels and adapt to stress. 

Orchilean works to help the body adapt to various stressful challenges such as those during high-intensity training or environmental stressors including pollutants and toxins. Specifically, Orchilean stimulates and replenishes the energy of cells and bodily systems that help regulate our state of homeostasis; by doing so we can adapt accurately to stress increasing our physical and psychological endurance and resiliency.

Orchilean also contains a biological peptide known as Cymbidine-A, a highly potent vasodilator and diuretic; in addition, it also contains an antioxidant known as Gigantol that works synergistically with Cymbidine-A to induce increased nitric oxide release.    

In this way, Orchilean works to enhance performance by improving stroke volume, blood flow, and increasing nitric oxide production to help deliver more oxygen and nutrients to working muscle tissue during training.

References:

  • Beg S, Swain S, Hasan H, Barkat MA, Hussain S. Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives. Pharmacogn Rev. 2011 Jul-Dec; 5(10): 120–137.
  • Bulpitt CJ, Yan Li, Bulpitt PF, Wang J. The use of orchids in Chinese medicine. J R Soc Med. 2007 Dec; 100(12): 558–563.

 

Higenamine:Higenamine is a molecule derived from a variety of fruits and plants that appears to have anti-asthmatic properties via dilating the bronchial tubes (a mechanism known as Beta(2)adrenergic agonism).

This mechanism is also the same one underlying the fat-burning potential of ephedrine, and as such Higenamine is currently being used as a fat burner.

Currently, there is no human evidence using Higenamine and it appears to be similarly potent to some established beta(2)adrenergic agonists in preliminary studies (in regards to anti-asthmatic effects). 

Beyond that mechanism, it may also exert anti-inflammatory effects and injections may be useful in a clinical setting against sepsis

References;

  • ACTA Pharmacol Sin. 2008; 29:1187-94

 

Huperzine A:Huperzine A (HupA) is an alkaloid extracted from the club moss (Huperzia serrata). It has demonstrated both memory enhancement and neuroprotective effects in animal and clinical trials. 

It’s mechanisms of action are:

  • Inhibits and enzyme that breaks down acetylcholine: Huperzine A is a potent, reversible, and specific inhibitor of the enzyme acetylcholine esterase (ACHE), which breaks down acetylcholine, although huperzine A also has other brain-supporting effects that do not involve ACHE.
  • Increases acetylcholine: Huperzine A increases acetylcholine levels in rat brains for up to 6 hours post-administration. Huperzine A results in a more prolonged increase in acetylcholine in the whole brain than tacrine, physostigmine, and metrifonate.
  • Increases Norepinephrine and Dopamine, but not Serotonin: Huperzine A increases levels of norepinephrine and dopamine, but not that of serotonin.

The health benefits of Huperzine A are Neuroprotecive:

  • Protects against toxic organophosphates
  • Protects neurons against glutamate toxicity
  • Protects the brain from oxidative damage
  • Helps With Recovering from Traumatic Brain Injury and Spinal Cord Injury
  • May Prevent and Treat Alzheimer’s Disease

 

HupA suppressed the production of Reactive Oxygen Species on HT22 cells under glutamate stimulation. Cells were treated with 10 μM of HupA for 24 h, followed by treatment of 5 mM glutamate for 12 h. Results were presented as mean ± SD (n = 8). ** p < 0.01 versus control group; ## p < 0.01 versus glutamate-treated group

References:

  • Pharmacol Biochem Behav. 2003 Jun;75(3):675-86.
  • Trends Pharmacol Sci. 2006 Dec;27(12):619-25. Epub 2006 Oct 23
  • J Neurosci Res. 1989 Oct;24(2):276-85
  • J Neurosci Res. 1995 Aug 15;41(6):828-35.
  • Fundam Clin Pharmacol. 1997;11(5):387-94.
  • Neuroscience. 2001;105(3):663-9
  • Cell Mol Neurobiol. 2016 Aug;36(6):915-925
  • Neuropsychiatr Dis Treat. 2015 Oct 13;11:2649-57
  • Int J Clin Exp Pathol. 2015 Jun 1;8(6):6425-33

AMPED-AF is the pre-workout you have been missing.

Dr. Paul Henning, PhD

About Dr. Paul

I'm currently an Army officer on active duty with over 15 years of experience and also run my own health and wellness business. The majority of my career in the military has focused on enhancing Warfighter health and performance. I am passionate about helping people enhance all aspects of their lives through health and wellness. Learn more about me