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October 07, 2019 7 min read

High-performance thinking is the key to getting ahead in today's fast-paced world.

From business executives, and professional athletes to students and everyone in between, people are looking to optimize their brains for improved memory and focus, faster thought processing and of course long-term brain health.

And that's why we created FOCUSED-AF.

What is FOCUSED-AF?

FOCUSED-AF is a mental support formula designed to help brain function, heighten the senses, sharpen the mind and encourage focus and mental clarity. It's the strongest over the counter alternative for those seeking intense focus.

Here's How it Works.

FOCUSED-AF combines the unique characteristics of several high-grade nootropics shown to enhance memory, attention, and focus, reduce mental errors, and act as an overall neuroprotective agent. This exclusive combination offers a synergistic effect that will optimize your cognitive abilities so you can perform at your best.

Here's what's in it:

Vitamin B6 (as Pyridoxine HCI):  Vitamin B6, also known as pyridoxine, is a water-soluble vitamin that your body needs for several functions.  It’s significant to protein, fat and carbohydrate metabolism and the creation of red blood cells and neurotransmitters.  Your body cannot produce vitamin B6, so you must obtain it from foods or supplements.  Consuming adequate amounts of vitamin B6 is important for optimal health and may even prevent and treat chronic diseases.  

Here are 9 health benefits of vitamin B6, backed by science:

  1. May improve mood and reduce symptoms of depression
  2. May promote brain health and reduce Alzheimer’s risk
  3. May prevent and treat anemia by aiding hemoglobin production
  4. May be useful in treating symptoms of PMS
  5. May help treat nausea during pregnancy
  6. May prevent clogged arteries and reduce heart disease risk
  7. May help prevent cancer
  8. May promote eye health and prevent eye diseases
  9. May treat inflammation associated with Rheumatoid arthritis
(National Institutes of Health: Office of Dietary Supplements)


Vitamin B12 (as Methylcobalamin):  Vitamin B12, also known as cobalamin, is an essential vitamin that your body needs but cannot produce.  It’s found naturally in animal products, but also added to certain foods and available as an oral supplement or injection.  Vitamin B12 has many roles in your body. It supports the normal function of your nerve cells and is needed for red blood cell formation and DNA synthesis.  Vitamin B12 may benefit your body in impressive ways, such as by boosting your energy, improving your memory and helping prevent heart disease.

Here are 9 health benefits of vitamin B12, all based on science.

  1. Helps With Red Blood Cell Formation and Anemia Prevention
  2. May Prevent Major Birth Defects
  3. May Support Bone Health and Prevent Osteoporosis
  4. May Reduce Your Risk of Macular Degeneration
  5. May Improve Mood and Symptoms of Depression
  6. May Benefit Your Brain by Preventing the Loss of Neurons
  7. May Give You an Energy Boost
  8. May Improve Heart Health by Decreasing Homocysteine
  9. Supports Healthy Hair, Skin and Nails

(Food Nutr Bull. 2008 Jun;29(2 Suppl):S101-11; discussion S112-5)


Alpha GPC 50% (L-Alpha-glyceryl phosphorylcholine): a natural choline compound found in the brain and one of the most bioavailable forms of choline. It is known to enhance a chemical in the brain called acetylcholine which is crucial for memory and learning functions. Alpha GPC can support cognitive health, improve memory, and learning, and it also acts as a neuroprotective agent. The main mechanism of action is by increasing acetylcholine and dopamine in the brain which is known to significantly enhance brain function. (Clin Ther. 2003 Jan;25(1):178-93)



Bacopa (Bacopa monnieri)(whole plant)(std for 20% bacosides): Bacopa monnieri has been used by Ayurvedic medical practitioners for centuries for a variety of purposes, including improving memory and reducing anxiety. Research indicates it may boost brain function and alleviate anxiety and stress, among other benefits. A class of powerful compounds called bacosides in Bacopa monnieri is believed to be responsible for these benefits.  

Below are seven emerging benefits of Bacopa monnieri:

  1. Contains powerful antioxidants
  2. May reduce inflammation
  3. May boost brain function
  4. May help reduce ADHD symptoms
  5. May prevent anxiety and stress
  6. May help lower blood pressure levels
  7. May have anticancer properties

(J Altern Complement Med. 2008 Jul; 14(6): 707–713)

Lutemax 2020 (Lutein & Zeaxanthin): Out of more than 600 carotenoids found in nature, the three macular carotenoids—lutein, RR-zeaxanthin, and RS (meso)-zeaxanthin—have garnered considerable attention for their role in preserving healthy vision. There is a growing agreement that macular carotenoids are conditionally essential nutrients, which is to say that under certain circumstances, supplementation may be required. Poor dietary intake increased blue light exposure, and current lifestyle changes are driving a greater need to supplement with these important nutrients to ensure adequate levels throughout life.

In addition to the health benefits to vision, the macular carotenoids within Lutemax 2020 are beneficial for:

  • Better bioavailability - Lutemax 2020 rapidly increased serum levels of lutein and zeaxanthin in association with increased macular pigment optical density (MPOD) in as little as 8-weeks.
  • Improved visual performance - Lutemax 2020 consistently improved contrast sensitivity, photo-stress recovery, and disability glare thresholds
  • The B.L.U.E. study – This study was the first human clinical trial in young, healthy subjects and there were improvements in outcomes associated with prolonged blue light exposure from digital devices, including eye strain and fatigue, headache frequency, and glare tolerance.
  • Stress and mood support - Lutemax 2020 significantly reduced stress, serum cortisol, and symptoms of suboptimal emotional and physical health and highlighted the importance of macular carotenoids for daily stress support.
  • Cognitive support - Lutemax 2020 increased brain-derived neurotrophic factor (BDNF), which is a key molecule involved in plastic changes related to learning and memory. It improved several parameters of cognitive performance, including composite memory, verbal memory, sustained attention, psychomotor speed, and processing speed.
  • Sleep quality - Blue light plays a role in regulating sleep/wake cycles, and Lutemax 2020 significantly improves sleep quality in subjects exposed to prolong blue light from sources such as digital devices.
  • Skin health - Photoaging is responsible for 90 percent of visible changes to the skin and carotenoids like lutein can help support a healthier, younger-looking appearance.
  • Safety – The safety of Lutemax 2020 was been established through in vitro, animal, and human studies. These studies were the basis of Lutemax 2020’s US FDA-notified GRAS affirmation.

 

 

 Fig: Change in scores at 6 months in placebo vs. combined supplement groups (MXan), for five parameters of cognitive performance. Data points are means +/− standard deviations. Asterisks indicate statistical significance ( p < .05).

(N.T. Stringham, P.V. Holmes, J.M. Stringham, Physiol. Behav. 211 (2019).)

Natural Caffeine (from Green Tea):  Natural caffeine is the type of caffeine that is naturally found in foods like coffee, tea, and chocolate. It works by blocking adenosine receptors in your brain.

Adenosine is a neurotransmitter that relaxes your brain, making you feel tired. By blocking adenosine receptors, caffeine prevents adenosine from binding to them. This keeps your brain from realizing that it’s tired, which is why caffeine is so effective at fighting off sleepiness and helping you remain more alert.

Even though natural and synthetic caffeine have the same bodily effects, here are a couple benefits of natural caffeine:

  • Foods With Natural Caffeine Are More Nutrient-Rich - Foods with natural caffeine are nutrient-rich. Natural caffeine contains antioxidants and nutrients like manganese, potassium, magnesium, and several types of B vitamins.
  • Natural Caffeine May Have Fewer Harmful Compounds - Natural caffeine does not contain harmful chemical compounds like ammonia, urea, or chloroform. And natural caffeine does not have a blueish glow.

(Justin Evans, John R. Richards, Amanda S. Battisti; Caffeine  StatPearls)

Mucuna Pruriens Extract (std to 98%)  Mucuna is a tropical legume that’s very rich in L-Dopa—L-Dopa is the precursor to dopamine, norepinephrine, and epinephrine. It can promote healthy neurotransmission function and enhance your mood and immune system.  The mechanism of action for mucuna is by increasing dopamine in the brain. This brain chemical (or neurotransmitter) is responsible for modulating several cognitive functions including mood, hand-eye-coordination, and others.

Mucuna can be a powerful tool to improve memory and cognitive abilities.  Research indicates that L-DOPA was able to prevent the decrease in testosterone levels which is thought to be due to dopamine’s ability to inhibit prolactin (a hormone responsible for lowering the levels of luteinizing hormone and testosterone). In addition, mucuna was shown to increase testosterone levels in infertile men from ages 25 to 40. (J Young Pharm. 2011 Apr;3(2):119-24)

Huperzine A 1% (Huperzia serrata Leaf Extract): Huperzine-A is an alkaloid extracted from club moss (Huperzia Serrata) that has demonstrated both memory enhancement and neuroprotective effects in animal and clinical trials.

Its mechanisms of action are:

Inhibits an enzyme that breaks down acetylcholine: Huperzine-A is a potent, reversible, and specific inhibitor of the enzyme acetylcholinesterase (ACHE), which breaks down acetylcholine. In addition, huperzine A also has other brain-supporting effects that do not involve ACH.

Increases acetylcholine: Huperzine-A increases acetylcholine levels in rat brains for up to 6 hours post-administration. Huperzine-A results in a more prolonged increase in acetylcholine in the whole brain than tacrine, physostigmine, and metrifonate.

Increases norepinephrine and dopamine: Huperzine-A increases levels of norepinephrine and dopamine.

Here are a few of the health benefits of Huperzine-A:

  • Protects against toxic organophosphates
  • Protects neurons against glutamate toxicity
  • Protects the brain from oxidative damage
  • Helps with recovering from traumatic brain injury and spinal cord injury
  • May prevent and treat Alzheimer’s disease

Fig: Huperzine-A suppressed the production of Reactive Oxygen Species on HT22 cells under glutamate stimulation. Cells were treated with 10 μM of HupA for 24 h, followed by treatment of 5 mM glutamate for 12 h. Results were presented as mean ± SD (n = 8). ** p < 0.01 versus control group; ## p < 0.01 versus glutamate-treated group.

(Pharmacol Biochem Behav. 2003 Jun;75(3):675-86.)

 

Saffron Extract (Crocus sativus) (flower): Saffron is a spice derived from the flower Crocus sativus and has traditionally been used to flavor food. Saffron contains a host of plant compounds that act as powerful antioxidants and protect cells against free radicals and oxidative stress that can lead to cancer. These compounds are thought to have antidepressant effects, protect brain cells against damage, decrease inflammation, and reduce appetite.

Evidence points to its ability to help improve mood, memory, and protect the brain against oxidative stress.  There are some studies that indicate that the antioxidants in saffron tea can help reduce the risk of cardiovascular diseases. Researchers also note that the flavonoids found in saffron also can provide protection. (Rezaee R, Hosseinzadeh H. Safranal: Iran J Basic Med Sci. 2013;16(1):12-26)

 

Check out these impressive results in memory & reaction time:

REACTION TIME

In a double-blind, placebo-controlled study, key ingredients in FOCUSED-AF were shown to decrease reaction time and increase stimulus detection (i.e. higher percentage correct)

MEMORY

During a double-blind, placebo-controlled, randomized study, there was a positive correlation between working memory capacity (on the x-axis: listening span) and influence of key ingredient in FOCUSED-AF (on the y-axis)

During a double-blind, placebo-controlled, randomized study, an ingredient (sulbutiamine=S) in FOCUSED-AF at doses of 12.5 mg/kg (S 12.5) and 25 mg/kg (S 25) greatly increased memory performance (mean; S.E.)

Now you can feel the benefits of being able to hold off fatigue, optimize the way you think, increase productivity and remain calm in stressful situations, and stay  FOCUSED-AF.

No matter if you're a business professional, an athlete, a creative, or a busy Mom with kids, if you're looking for an edge to help boost your cognitive function and improve your focus and memory, look no further than FOCUSED-AF.

Dr. Paul Henning, PhD

About Dr. Paul

I'm currently an Army officer on active duty with over 15 years of experience and also run my own health and wellness business. The majority of my career in the military has focused on enhancing Warfighter health and performance. I am passionate about helping people enhance all aspects of their lives through health and wellness. Learn more about me