Type 2 diabetes is a serious disease that has become incredibly common in recent decades causing millions of deaths every year. It's characterized by elevated blood sugar (glucose) levels caused by insulin resistance or lack of insulin. Over time high blood sugar levels can damage the body’s tissues and organs, leading to numerous health problems and a shortened lifespan.
ADALOAD is a potent combination of ingredients shown in evidence-based research to reduce blood sugar levels in individuals with high blood glucose.
In this article, we'll break down in detail each of these ingredients so you can decide for yourself whether ADALOAD is right for you. Sound good? Ok, let's get started.
The mechanisms through which the ingredients in ADALOAD helps prediabetes is by activating an enzyme called Adenosine Monophosphate-Activated Protein Kinase (AMPK) while inhibiting Protein-Tyrosine Phosphatase 1B (PTP1B). It also contributes to favorable insulin levels by increasing insulin production and regenerating insulin-secreting islet cells. Both can help lower blood sugar levels.
It helps your cells utilize glucose and move it to your liver, muscles, and fat and your body retain nutrients by blocking their conversion to glucose that ends up in your bloodstream. Another mechanism through which ADALOAD works is that it reduces insulin resistance by increasing phosphatidylinositol 3-kinase activity in the insulin-signaling pathway and thus potentiating insulin action.
Berberine is a compound extracted from a variety of herbs. It is supplemented for its anti-diabetic effects, which rival the potency of some pharmaceuticals. In fact, its effectiveness is comparable to the popular diabetes drug metformin (Glucophage).
It can also improve intestinal health and lower cholesterol. Berberine is able to reduce glucose production in the liver. Berberine’s main mechanism is partly responsible for its anti-diabetic and anti-inflammatory effects. Berberine is able to activate an enzyme called Adenosine Monophosphate-Activated Protein Kinase (AMPK) while inhibiting Protein-Tyrosine Phosphatase 1B (PTP1B). (Biochem Cell Biol. 2015 Oct;93(5):479-86, J Ethnopharmacol. 2015 Feb 23;161:69-81, Metabolism. 2008 May;57(5):712-7)
Fig: Both berberine and metformin decreased FBG and PBG of type 2 diabetes mellitus patients significantly from week 1 to week 13. A, Means ± SEM of 15 patients treated with berberine alone. B, Means ± SEM of 16 patients treated with metformin alone. C, Means ± SEM of 43 patients with combination therapy including berberine. Metabolism. 2008 May;57(5):712-7
Gymnema Sylvestre is a woody climbing shrub that’s native to the tropical forests of India, Africa, and Australia. Gymnemic acids in Gymnema Sylvestre can block the sugar receptors on your tongue, decreasing your ability to taste sweetness. This can lead to reduced sugar cravings.
Gymnema Sylvestre has anti-diabetic properties and may lower your blood sugar levels after a meal. Gymnema Sylvestre appears to contribute to favorable insulin levels by increasing insulin production and regenerating insulin-secreting islet cells. Both can help lower blood sugar levels. (J Clin Biochem Nutr. 2007 Sep;41(2):77-81, Curr Pharm Des. 2017;23(11):1667-1676, Diabetes In Control Newsletter, Issue 76 (1): 30 Oct 2001, J Sci Food Agric. 2014 Mar 30;94(5):834-40)
Fig: Effect of Extended-Release Gymnema Sylvestre Leaf Extract (Beta Fast GXR). White bars represent readings pre-Beta Fast use. Black bars represent post-Beta Fast use. Diabetes In Control Newsletter, Issue 76 (1): 30 Oct 2001
Bitter melon (also known as Momordica charantia, bitter gourd, wild cucumber, and more) is a plant that gets its name from its taste. It becomes more and more bitter as it ripens. It grows in a number of areas (including Asia, South America, the Caribbean, and East Africa) where people have used bitter melon for a variety of medical conditions over time. Bitter melon is linked to lowering the body’s blood sugar. This is due to the properties of bitter melon that act like insulin, which helps bring glucose into the cells for energy. Bitter melon can help your cells utilize glucose and move it to your liver, muscles, and fat. The melon may also be able to help your body retain nutrients by blocking their conversion to glucose that ends up in your bloodstream. (Cochrane Database Syst Rev. 2012 Aug 15;(8)
Alpha-lipoic acid (ALA) is a mitochondrial compound involved in energy metabolism. Alpha-lipoic acid has become popular as a potential aid for diabetes, as it’s been shown to lower blood sugar levels in both animals and humans. Studies done in adults with metabolic syndrome have shown that it may reduce insulin resistance and lower fasting blood glucose and HbA1c levels. The main mechanism of action is that it helps lower blood sugar by promoting processes that can remove fat that has accumulated in muscle cells, which otherwise make insulin less effective. Moreover, alpha-lipoic acid may lower the risk of diabetes complications.
It’s proven to ease symptoms of nerve damage and lower the risk of diabetic retinopathy (eye damage) that can occur with poorly controlled diabetes. This mechanism of action is due to the powerful antioxidant properties of alpha-lipoic acid. (J Clin Biochem Nutr. 2011 Jan;48(1):26-32, Front Pharmacol. 2011 Nov 17;2:69, Metabolism. 2018 Oct;87:56-69, Diabetes Educ. 2007 Jan-Feb;33(1):111-7, Pharmacol Rep. 2011;63(4):849-58)
Fig: The α-LA lowers blood glucose levels in diabetic mice.
Biochem Biophys Res Commun. 2018 Sep 10;503(3):1307-1314
After years of investigation, Cinnulin PF® was developed as a water-soluble extract from the bark of the Cinnamomum Burmannii tree (also known as Indonesian Cassia) using a proprietary extraction process called Controlled Polymer Purification Technology (CPPT). This process allows the important, biologically active compounds to be isolated from the potential toxins from the whole cinnamon. The mechanism of action of Cinnulin PF® is that it reduces insulin resistance by increasing phosphatidylinositol 3-kinase activity in the insulin-signaling pathway and thus potentiating insulin action. In addition, adipocytes treated with cinnamon extract in vitro increase the glucose uptake and glycogen synthesis by these mechanisms (J Diabetes Sci Technol. 2010 May 1;4(3):685-93)
Fig: Beneficial effects of an aqueous extract of cinnamon on glucose, blood pressure, percent body fat, and lean mass of subjects with metabolic syndrome. FBG, fasting blood glucose; SBP, systolic blood pressure. J Diabetes Sci Technol. 2010 May 1;4(3):685-93
Capric acid is present in minute amounts in human milk and in plant oils like coconut and seed oils. Because of its presence in food, sodium caprate is approved by the FDA as a direct food additive for human consumption.
The mechanism of action is by enhancing absorption kinetics of other ingredients/molecules through the intestinal membrane by increasing permeability through both the paracellular and transcellular routes.
Vanadium is a mineral that is not one of the Essential Mineral compounds, but is sometimes ingested in the diet. Can be found in bone tissues, Vanadium may influence glucose metabolism in an anti-diabetic manner. The mechanism is that insulin eventually suppresses its own signaling via stimulating PTP enzymes (including PTP1B) which degrade IRS-1, the degradation of IRS-1 then curtails further insulin signaling. Vanadium, like other PTP inhibitors, can prolong the signaling of insulin by preventing the degradation of IRS-1. (Metabolism. 2003 Jun;52(6):666-74.)
Prediabetes is a wakeup call that you’re on the path to diabetes but it's not too late to turn things around. If you have it (like 86 million other Americans), your blood sugar (glucose) level is higher than it should be, but not in the diabetes range. If you have prediabetes, the long-term damage of diabetes — especially to your heart, blood vessels, and kidneys — may already be starting.
