November 15, 2019 11 min read

If you're looking to shed unwanted belly fat and get in the best shape of your life then a thermogenic fat burner like SHREDDED-AF could be exactly what you're looking for to help kick your body into high gear in terms of its fat-burning potential. 

Comprised of the purest and most potent ingredients that are backed by science, SHREDDED-AF is an advanced multi-stage thermogenic that focuses on boosts metabolism, suppresses cravings, and provides all-day energy and mental clarity without the crash.

In this article, we'll breakdown the extensive list of ingredients and provide verified before and after photos of customers who have used SHREDDED-AF to incinerate stubborn fat that plagued them for years, so let's get into it.

These potent ingredients are backed by science to help optimize:

  • Energy & Focus*
  • Appetite Suppression*
  • Fat Mobilization Thermogenic*
  • Neuroprotective*
  • Anti-inflammatory*

Vitamin B6 (as Pyridoxine HCL): Vitamin B6, also known as pyridoxine, is a water-soluble vitamin that your body needs for several functions. It’s significant to protein, fat and carbohydrate metabolism and the creation of red blood cells and neurotransmitters. 

Your body cannot produce vitamin B6, so you must obtain it from foods or supplements. Consuming adequate amounts of vitamin B6 is important for optimal health and may even prevent and treat chronic diseases.

Here are 9 health benefits of vitamin B6, backed by science:

1. May improve mood and reduce symptoms of depression
2. May promote brain health and reduce Alzheimer’s risk
3. May prevent and treat anemia by aiding hemoglobin production
4. May be useful in treating symptoms of PMS
5. May help treat nausea during pregnancy
6. May prevent clogged arteries and reduce heart disease risk
7. May help prevent cancer
8. May promote eye health and prevent eye diseases
9. May treat inflammation associated with Rheumatoid arthritis

References:

  • National Institutes of Health: Office of Dietary Supplements
  • Molecules. 2010 Jan 20;15(1):442-59
  • Psychother Psychosom 2004 Nov-Dec;73(6): 340-3

Vitamin B12: Vitamin B12, also known as cobalamin, is an essential vitamin that your body needs but cannot produce. t’s found naturally in animal products but also added to certain foods and available as an oral supplement or injection. 

Vitamin B12 has many roles in your body. It supports the normal function of your nerve cells and is needed for red blood cell formation and DNA synthesis. Vitamin B12 may benefit your body in impressive ways, such as boosting your energy, improving your memory and helping prevent heart disease.

Here are 9 health benefits of vitamin B12, all based on science:

1. Helps with Red Blood Cell Formation and Anemia Prevention

2. May Prevent Major Birth Defects

3. May Support Bone Health and Prevent Osteoporosis

4. May Reduce Your Risk of Macular Degeneration

5. May Improve Mood and Symptoms of Depression

6. May Benefit Your Brain by Preventing the Loss of Neurons

7. May Give You an Energy Boost

8. May Improve Heart Health by Decreasing Homocysteine

9. Supports Healthy Hair, Skin and Nails

References:

  • Food Nutr Bull. 2008 Jun;29(2 Suppl): S101-11; discussion S112-5.
  • Arch Gynecol Obstet. 2009 Sep;280(3):381-7
  • Arch Intern Med. 2009 Feb 23; 169(4): 335–341.
  • Open Neurol J. 2013; 7: 44–48.
  • Am J Clin Nutr. 2016 Apr;103(4):1045-54
  • PLoS One. 2012;7(1):e30519.
  • Front Public Health. 2014 Aug 6;2:112
  • Can Fam Physician. 2008 Apr; 54(4): 529–532.

Folate (as Folic Acid): Folate is the naturally occurring form of vitamin B9. Vitamin B9 is an essential nutrient that naturally occurs as folate. 

It serves many important functions in your body like playing a crucial role in cell growth and the formation of DNA. Low levels of vitamin B9 are associated with an increased risk of several health conditions, including:

  • Elevated homocysteine. High homocysteine levels are shown to be associated with an increased risk of heart disease and stroke
  • Birth defects. Low folate levels in pregnant women have been linked to birth abnormalities, such as neural tube defects
  • Cancer risk. Modest levels of folate are also linked to increased cancer risk

For these reasons, supplementing with vitamin B9 is common. Fortifying food with this nutrient is mandatory in many countries, including the United States and Canada.

References:

  • Diab Vasc Dis Res. 2007 Jun;4(2):143-50
  • Nutrients. 2013 Nov 21;5(11):4760-75
  • J Nutr. 2002 Aug;132(8 Suppl):2413S-2418S

Caffeine Anhydrous: Caffeine increases focus and mental stimulation. One of the main mechanisms is by increasing adrenaline. Adrenaline is a powerful stimulatory chemical, but not the only mechanism of caffeine.

The primary mechanism that makes caffeine unique is adenosine activity (as a receptor antagonist), which essentially helps increase alertness and reduce feelings of lethargy. There are some studies to suggest caffeine has a positive effect on memory formation. In addition, caffeine and coffee have been shown to cause major improvements in performance for endurance athletes. 

For high-intensity sports like cycling or swimming, caffeine may benefit trained athletes but not untrained individuals. For strength or power-based exercises, the research about the effects of caffeine is mostly positive but still mixed. 

Caffeine can help release stored fat from fat cells, especially before and at the end of a workout. It can also help you burn more calories.

References:

  • J Alzheimers Dis. 2010;20 Suppl 1:S85-94
  • Br J Sports Med. 1992 Jun; 26(2): 116–120.
  • Int J Sport Nutr Exerc Metab. 2008 Aug;18(4):412-29
  • Med Sci Sports Exerc. 2010 Jul;42(7):1375-87
  • Am J Physiol. 1992 Jun;262(6 Pt 1): E891-8

Beta Phenylethlamine: Phenylethylamine (PEA) is a hormone-like substance that occurs naturally in your brain and body. It functions as a neurotransmitter that gives you heightened focus, attention, goal-directed behavior, and task-completion. 

Combined with its mood-elevating effects, these attributes are why supplementation with PEA can bring about increased get-up-and-go, enhanced sense of well-being, and optimal cognitive performance. Moreover, PEA amplifies the actions of other key brain chemicals – serotonin, dopamine, norepinephrine, and acetylcholine. 

As such, PEA is thought to slow down the rate at which your brain and body age, extend healthspan, and increase longevity. Proper supplementation with PEA is designed to provide rapid improvements on mental clarity, mood, stamina, energy, libido, joy, and motivation.

References:

  • Proc Natl Acad Sci U S A. 1982 Oct;79(20):6385-9

N-Acetyl-L-Tyrosine: Tyrosine is an amino acid that's naturally produced in the body from another amino acid called phenylalanine and produces important brain chemicals that help nerve cells communicate and may even regulate mood. 

Tyrosine is a popular dietary supplement used to improve alertness, attention, and focus and studies show that tyrosine can help maintain your mental capacity when taken before a stressful activity.

Tyrosine is found in chicken, turkey, fish, dairy products and most other high-protein foods. 

Tyrosine helps make several important substances, including:

  • Dopamine: Dopamine regulates your reward and pleasure centers. This important brain chemical is also important for memory and motor skills.
  • Adrenaline and noradrenaline: These hormones are responsible for the fight-or-flight response to stressful situations. They prepare the body to “fight” or “flee” from a perceived attack or harm.
  • Thyroid hormones: Thyroid hormones are produced by the thyroid gland and primarily responsible for regulating metabolism.
  • Melanin: This pigment gives your skin, hair, and eyes their color. Dark-skinned people have more melanin in their skin than light-skinned people.

Supplementing with tyrosine is thought to increase levels of the neurotransmitter’s dopamine, adrenaline, and norepinephrine. By increasing these neurotransmitters, it may help improve memory and performance in stressful situations. 

References:

  • J Psychiatry Neurosci. 2007 May; 32(3): 224
  • J Nutr. 2007 Jun;137(6 Suppl 1):1539S-1547S
  • Physiol Rev. 2014 Apr; 94(2): 355–382.
  • Pigment Cell Melanoma Res. 2012 Jan;25(1):14-27

N-Phenethyl Dimethylamine: N-Phenethyl Dimethylamine provides therapeutic mood-boosting effects due to its ability to increase levels of dopamine and noradrenaline the body. Dopamine is the 'feel-good' hormone responsible for giving users a euphoric sensation.

These hormones are also associated with enhancing concentration levels, alertness and focus. Therefore, supplementing with N-Phenethyl Dimethylamine can increase the quality of one’s training, assist with fat loss, and improve general concentration levels during the day.

Phenethylamine can be derived from Eria Jarenis, an Orchid species local to countries such as China and Southeast Asia. It can be classified as a neuromodulator on the Central Nervous system, yielding a myriad of attractive benefits for your cognitive function.

References:

  • Prog Neuropsychopharmacol Biol Psychiatry. 2012 Dec 3;39(2):263-72

Hordenine HCL: Hordenine, known by its scientific name as N, N-dimethyltyramine, is an alkaloid mainly found in plants such as barley that are used as feed for animals. 

It is adrenergic, meaning it causes nerve cells to release the neurotransmitters epinephrine (adrenaline) and norepinephrine (noradrenaline). Molecules like epinephrine and norepinephrine increase energy and focus and are part of the “fight-or-flight” response.

Health benefits of Hordenine:

  • May increase alertness: Hordenine has been shown to increase alertness within two minutes.
  • May increase energy: Hordenine increases response to noradrenaline, therefore causes increased energy and focus after consumption.

Figure a: Reaction time: Average number of hits. * = Significant difference (p < 0.05) between the supplement and placebo.
Figure b: Reaction time: Average percentage of successful hits from total possible targets. * = Significant difference (p < 0.05) between the supplement and placebo. Data are reported as mean ± SD

References:

  • Dtsch Tierarztl Wochenschr. 1995 Jun;102(6):228-32
  • Neurochem Res. 2012 Nov; 37(11): 2496–2512.
  • J Int Soc Sports Nutr. 2009; 6: 2

ParadoxineTM (std to 12.5% 6 Paradol): Paradoxine®, is a patented, standardized extract of Grains of Paradise that provides body re-composition benefits, without impacting your cardiovascular system.

To understand how Paradoxine works in the body it helps to understand the different types of adipose tissue (a.k.a. fat) in your body.

There are two types of fat in the body:

Brown Adipose Tissue (BAT)

White Adipose Tissue (WAT)

White Fat is your body’s energy storage cells. Whatever extra calories aren’t immediately needed by the body are stored as “white” fat and are used when food intake is reduced. White fat cells are large, round cells comprised of one big lipid droplet with a thin rim containing the nucleus and cytoplasm

Brown Fat, on the other hand, is the fat used for diet and cold-induced thermogenesis, maintaining your body’s normal temperature when exposed to cold. The technical term for this is “non-shivering thermogenesis.” Brown fat cells aren’t only different in function than white fat cells, they’re structure is also different. Brown fat cells are comprised of smaller diameter cells, containing several smaller fat droplets compared to the one massive droplet that’s found in white fat.

The power of Paradoxine® lies in its ability to transform white fat cells into brown fat cells, increasing energy expenditure and boosting weight loss. An added benefit to brown fat is that it can use blood sugar (glucose) and fats, leading to improved lipid levels and glucose metabolism, independent of weight loss!

References:

  • Adipocyte. 2014 Jan 1; 3(1): 4–9.
  • Diabetes Metab J. 2016 Feb; 40(1): 12–21.

N Methyl Tyramine: N-Methyltyramine, also known as 4-hydroxy-N-methylphenethylamine, is a human trace amine and natural phenethylamine alkaloid found in a variety of plants.

NMT supplementation is unquestionably effective for bodybuilding enthusiasts and athletes alike. Since N-methyltyramine is a neuromodulator, the main advantages of NMT supplementation are cognitive improvements such as enhanced motivation, increased focus, and a greater sense of urgency.

The mental benefits of NMT translate to physical benefits as well, like better athletic performance, elevated thermogenesis (calorie expenditure), and thus, improved fat loss.

References:

  • Gainetdinov, R. R., Hoener, M. C., & Berry, M. D. (2018). Trace amines and their receptors. Pharmacological Reviews, 70(3), 549-620.
  • Yokoo, et al. (1999). Isolation from beer and structural determination of a potent stimulant of gastrin release. Alcohol and alcoholism (Oxford, Oxfordshire), 34(2), 161-168.

Theophylline: Theophylline is a relatively weak bronchodilator containing a chemical similar to caffeine that relaxes the smooth muscle surrounding the airways, essentially making it easier to breathe.

It belongs to a class of drugs called methylxanthines that work in a similar way and treat similar conditions.

References:

  • Int J Cosmet Sci. 2019 Oct 21

Isopropylnorsynephrine: Isopropylnorsynephrine accomplishes what its cousin synephrine has always claimed to do, and that is increase fat loss. While synephrine is far more common, it has been shown to be only marginally effective at stimulating weight loss, while isoproylnorsynephrine was found to be “clearly lipolytic” in the aforementioned study. 

The mechanism of action are through its lipolytic affect as it was capable of breaking down lipids (fats) and triglycerides into glycerol and free fatty acids. Once these are broken down, the body is capable of using them as energy/fuel, resulting in body fat stores being “burned”.

Its stimulatory mechanism of action is likely through similar mechanisms as synephrine itself, agonizing beta receptors and antagonizing alpha-adrenergic receptors.

References:

  • J Physiol Biochem. 2011 Sep;67(3):443-52

LeanGBBTM (Gamma-aminobutyric acid): Gamma-aminobutyric acid (GABA) is a naturally occurring amino acid that works as a neurotransmitter in your brain. Neurotransmitters function as chemical messengers.

GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system. When GABA attaches to a protein in your brain known as a GABA receptor, it produces a calming effect. This can help with feelings of anxiety, stress, and fear. It may also help to prevent seizures. 

LeanGBBTMis Genabolix’s trademark ingredient of Gamma-Butyrobetaine (GBB), which is a precursor of L-carnitine. LeanGBBTMhas a fat loss function as it transforms into L-carnitine. Clinical studies clearly show that GBB dramatically increases endogenous (within the body) L-carnitine production. 

References:

  • J Nutr. 1987 Jun;117(6):1024-31

Bioperine (Black Pepper Fruit Extract): Bioperine is the active ingredient in black pepper that contributes to that unique spice you taste. Black pepper has long been regarded as beneficial to one’s health throughout history. Now with the help of modern science and clinical research, more Piperine benefits are being discovered.

Here are just several of those science-backed health benefits of black pepper extract. 

  • High in antioxidants: Black pepper is rich in a potent antioxidant called piperine, which may help prevent free radical damage to your cells.
  • Has anti-inflammatory properties: Chronic inflammation may be an underlying factor in many conditions, such as arthritis, heart disease, diabetes, and cancer. Many laboratory studies suggest that piperine — the main active compound in black pepper — may effectively fight inflammation.
  • May benefit your brain: Piperine has been shown to improve brain function in animal studies. In particular, it has demonstrated potential benefits for symptoms related to degenerative brain conditions like Alzheimer’s and Parkinson’s disease.
  • Boosts absorption of nutrients: Black pepper may increase the absorption of essential nutrients like calcium and selenium, as well as some beneficial plant compounds, such as those found in green tea and turmeric.
  • May have cancer-fighting properties: Black pepper contains an active compound that has slowed the replication of cancer cells and induced cancer cell death in test-tube studies. However, these effects have not been studied in people.

Effect of piperine on the production of proinflammatory mediators. Higher levels of piperine significantly reduced pro-inflammatory mediators.

References:

  • Redox Rep. 2004;9(2):105-10
  • J Transl Med. 2018 Jan 25;16(1):14
  • J Clin Diagn Res. 2015 Apr;9(4):FF01-4
  • Crit Rev Food Sci Nutr. 2013;53(9):875-86

Alpha Yohimbine: Yohimbe (Pausinystalia Yohimbe) is an evergreen tree native to western and central Africa. The bark of the tree contains an active compound called yohimbine which is traditionally used as an aphrodisiac. 

It works by blocking alpha-1 and alpha-2 adrenoceptors, increasing adrenaline and dopamine and decreasing serotonin levels. Blocking these receptors increases blood pressure, releases insulin and decreases blood sugar levels.

References:

  • Am J Pharm Educ. 2007 Aug 15;71(4):78.

Huperzine-A (Huperzia Serrata): Huperzine-A is an alkaloid extracted from the club moss (Huperzia Serrata) that has demonstrated both memory enhancement and neuroprotective effects in animal and clinical trials. 

It’s mechanisms of action are:

  • Inhibits an enzyme that breaks down acetylcholine: Huperzine-A is a potent, reversible, and specific inhibitor of the enzyme acetylcholine esterase (ACHE), which breaks down acetylcholine, although huperzine A also has other brain-supporting effects that do not involve ACHE
  • Increases acetylcholine: Huperzine-A increases acetylcholine levels in rat brains for up to 6 hours post-administration. Huperzine-A results in a more prolonged increase in acetylcholine in the whole brain than tacrine, physostigmine, and metrifonate
  • Increases norepinephrine and dopamine but not serotonin: Huperzine-A increases levels of norepinephrine and dopamine, but not that of serotonin

Here are a few of the health benefits of Huperzine-A:

  • Protects against toxic organophosphates
  • Protects neurons against glutamate toxicity
  • Protects the brain from oxidative damage
  • Helps With Recovering from Traumatic Brain Injury and Spinal Cord Injury
  • May Prevent and Treat Alzheimer’s Disease

Huperzine-A suppressed the production of Reactive Oxygen Species on HT22 cells under glutamate stimulation. Cells were treated with 10 μM of HupA for 24 h, followed by treatment of 5 mM glutamate for 12 h. Results were presented as mean ± SD (n = 8). ** p < 0.01 versus control group; ## p < 0.01 versus glutamate-treated group.

References:

  • Pharmacol Biochem Behav. 2003 Jun;75(3):675-86.
  • Trends Pharmacol Sci. 2006 Dec;27(12):619-25. Epub 2006 Oct 23
  • J Neurosci Res. 1989 Oct;24(2):276-85
  • J Neurosci Res. 1995 Aug 15;41(6):828-35.
  • Fundam Clin Pharmacol. 1997;11(5):387-94.
  • Neuroscience. 2001;105(3):663-9
  • Cell Mol Neurobiol. 2016 Aug;36(6):915-925
  • Neuropsychiatr Dis Treat. 2015 Oct 13;11:2649-57
  • Int J Clin Exp Pathol. 2015 Jun 1;8(6):6425-33

3,5 diiodo-l-thyronine: 3,5-diiodo-l-thyronine (T2) is an endogenous derivative of thyroid hormone that has been suggested to regulate energy expenditure, resting metabolic rate and oxygen consumption with a mechanism that involves the activation of mitochondrial function. 

Several reports have shown that, in rats, acute or chronic T2 administration causes significant changes in mitochondrial activities, stimulating fatty acid oxidation, and decreasing hepatic lipid accumulation.

Figure: Uptake of T2. Results of T2 uptake in H9c2 cell during 24 hours of incubation with 100 nM T2 in the medium. Assays were performed at different times in the incubation medium and in the cell lysate. Values are mean ± SEM of results derived from three uptake experiments.

References:

  • Molecular and Cellular Endocrinology, Volume 458, 15 December 2017, Pages 121-126
  • Front. Endocrinol., 30 May 2018
  • Goglia F. Biological effects of 3,5-diiodothyronine (T2). Biochemistry (Mosc) (2005) 70(2):164–72
  • O’reilly I, Murphy MP. Studies on the rapid stimulation of mitochondrial respiration by thyroid hormones. Acta Endocrinol (Copenh) (1992) 127(6):542–6

That's obviously a lot of scientific talk that may be hard to understand, so we'll show you how effective it is.

Check out these before and after pics...