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October 27, 2025 4 min read

Waking up repeatedly during the night to urinate is more than a simple inconvenience. It’s a widespread issue that quietly affects millions of adults and can have far-reaching consequences for health, sleep, and longevity(1).

Sleep is the body’s nightly repair cycle.

When that cycle is repeatedly interrupted, the body’s internal systems (especially the heart) begin to feel the strain. Over time, those disruptions can erode both physical and cardiovascular health.

It's called nocturia, and it's remarkably common.

Among younger adults (ages 20–40), roughly one in five to one in three report waking at least once a night to urinate(1,2)

In older adults, the numbers more than double(3).

Beyond the personal frustration of lost sleep, nocturia carries real societal costs. Frequent nighttime waking increases the risk of falls and injuries, particularly among older adults leading to billions of dollars in medical expenses each year. Factoring in lost productivity and absenteeism, the economic impact in the United States is estimated at more than $60 billion annually(4).

Why It Matters for Heart Health

Nocturia isn’t just about bladder control, it may reflect deeper problems with the body’s overall regulation. A growing body of research connects it to obesity, high blood pressure, diabetes, and cardiovascular disease and even to a higher risk of death from any cause(5).

One large U.S. study that followed nearly 14,000 adults for over three decades found that people who urinated more frequently at night faced a significantly higher risk of dying from heart disease and other causes.

The relationship followed a clear pattern: the more often participants woke to urinate, the higher their risk(5).

Other studies echo this finding. On average, people with nocturia are 20–25% more likely to die prematurely than those who sleep through the night, even after accounting for age, lifestyle, and medical history(6).

Why the Connection Exists

Researchers believe the link between nocturia and heart disease is twofold: nocturia may both signal underlying problems and contribute to them at the same time.

  • Sleep disruption: Each trip to the bathroom breaks up deep, restorative sleep. Missing this phase, known as 'slow-wave' or N3 sleep can heighten inflammation in blood vessels and impair the body’s repair processes, gradually raising cardiovascular risk(7).
  • Fluid shifts: During the day, fluid often pools in the legs, especially in people with heart or kidney problems. When lying down at night, that fluid re-enters circulation, prompting the kidneys to produce more urine(8).
  • Metabolic and hormonal factors: Poorly controlled diabetes increases urine production, and disruptions in hormone balance, particularly those governing fluid regulation can worsen the problem. Both mechanisms are also linked to heart disease(9).

Taken together, these factors suggest that nocturia can serve as an early warning sign of cardiovascular dysfunction rather than merely a side effect of aging.

Rethinking 'Normal' Aging

Many people, including some clinicians, still view waking to urinate as an unavoidable part of getting older. But research increasingly shows that this assumption can be misleading. While nocturia becomes more common with age, it’s not inevitable, and it often signals a treatable underlying condition.

Addressing nocturia early whether by improving sleep habits, managing blood pressure or blood sugar, or treating sleep apnea can improve both quality of life and long-term health outcomes.

What Can Be Done If It Starts To Happen To You?

If you’re waking multiple times each night, it’s worth discussing with a healthcare professional. 

Helpful steps may include(5):

  • Adjusting evening fluid intake or timing of medications
  • Managing underlying conditions such as diabetes, heart failure, or sleep apnea
  • Reviewing medications that may increase urine production
  • Considering targeted therapies when lifestyle measures are insufficient

The goal isn’t just uninterrupted sleep, the goal is restoring the body’s nightly recovery process and protecting long-term cardiovascular health.

The Takeaway From This Research

Frequent nighttime urination is often dismissed as a harmless nuisance, but mounting evidence suggests it may be an important indicator of heart and overall health. In large, long-term studies, nocturia consistently tracks with a higher risk of heart disease and premature death.

Nocturia is like a warning light on the dashboard. 

It doesn’t mean something is already broken. but it signals that something in the system deserves attention. Identifying and treating it early can help restore deeper sleep, support cardiovascular health, and improve overall well-being.

If you love getting a great night's sleep and want to wake up RESTED-AF you'll want to try this!

 

References: 
    1.    Hashim H, Blanker MH, Drake MJ, et al: International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. Neurourol Urodyn 38:499-508, 2019
    2.    Markland AD, Vaughan CP, Johnson TM, 2nd, et al: Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. J Urol 185:998-1002, 2011
    3.    Bosch JL, Weiss JP: The prevalence and causes of nocturia. J Urol 189:S86-92, 2013
    4.    Holm-Larsen T: The economic impact of nocturia. Neurourol Urodyn 33 Suppl 1:S10-4, 2014
    5.    Chen M, He W, Cai S, et al: Association of nocturia with cardiovascular and all-cause mortality: a prospective cohort study with up to 31 years of follow-up. Front Public Health 11:1292362, 2023
    6.    Fan Y, Wei F, Lang Y, et al: Meta-analysis of nocturia and risk of all-cause mortality in adult population. Int J Cardiol 195:120-2, 2015
    7.    Kim JW, Moon YT, Kim KD: Nocturia: The circadian voiding disorder. Investig Clin Urol 57:165-73, 2016
    8.    Hirayama A, Torimoto K, Yamada A, et al: Relationship between nocturnal urine volume, leg edema, and urinary antidiuretic hormone in older men. Urology 77:1426-31, 2011
    9.    Weiss JP: Nocturia: focus on etiology and consequences. Rev Urol 14:48-55, 2012

Dr. Paul Henning

About Dr. Paul

I'm currently an Army officer on active duty with over 15 years of experience and also run my own health and wellness business. The majority of my career in the military has focused on enhancing Warfighter health and performance. I am passionate about helping people enhance all aspects of their lives through health and wellness. Learn more about me