HYPERBOLIC: THE ULTIMATE ANABOLIC PRIMER AND HYPERTROPHIC CATALYST

If maximum muscle growth is your goal for every training session, you'll want to create the most anabolic environment possible so your body has the best opportunity to utilize the nutrients you feed it to increase muscle growth.

That's exactly why this revolutionary formula was created.

It's been 23 years in the making and it is the most comprehensive pre, intra, and post-workout sports nutrition formulation to ever be put on the market. Molded by IFBB Pro Bodybuilders and other professional athletes to elicit the highest rate of effectiveness possible, it is purely designed for athletes at the top of their game, where the complexity of this product can be fully utilized and appreciated.

What Is HYPERBOLIC?

HYPERBOLIC is a meticulously researched pre, intra, and post-workout formula designed to enhance anabolism, hypertrophy, muscular endurance, pumps, stamina, and nutrient assimilation throughout the entire workout process, spanning from warm-up to post-workout recovery.

This all encompassing approach ensures that dedicated athletes and fitness enthusiasts committed to their craft achieve maximized results with every training session.

Highlights include Glyco-X, a staple in ADABOLIC, to substantial dosages of vital compounds such as 6 grams of L-Citrulline, 2 grams of Beta Alanine, and 400 milligrams of N.O.7. STEEL has included an impressive 10 grams of Clear Whey Protein Isolate in each scoop of HYPERBOLIC, delivering protein-derived amino acids that support protein synthesis, recovery, and muscle fullness.

Ingredient Highlights: What They Are and What They Do

Glyco-X  (12g per scoop)

• What it is: Glyco-X is a carefully balanced blend of quick-acting carbohydrates sourced from rice and potato.
• What it does: Glyco-X shuttles the ingredients within Hyperbolic throughout the body, allowing for rapid nutrient assimilation.

Glyco-X has been shown to increase time to exhaustion and hydration, and the blood sugar stabilizing quality of Glyco-X allows people to stay energized and focused over long periods of exertion.  

The success of Glyco-X is tested and published in scientific research. Glyco-X is specifically formulated for the requirements of different sports⁽¹⁾.

Clear Whey Protein Isolate (10g/Scoop)

• What it is: Clear Whey Protein Isolate (WPI) is a high-purity protein powder. The amino acids found in HYPERBOLIC are all derived from actual protein as opposed to individually added amino acids. This ensures you are getting the ratios of amino acids that protein intended, enhancing muscle recovery.
• What it does: WPI is rapidly absorbed, allowing for muscle repair and enhanced rates of recovery.

Main benefits of Whey Protein Isolate

Whey protein is among the best studied supplements in the world, for good reason. It has a very high nutritional value, and scientific studies have revealed numerous health benefits.

• Whey protein promotes muscle growth.
• Whey is rich in a branched-chain amino acid called leucine, which is considered the most anabolic (growth promoting) of the amino acids⁽²⁾.
• Whey is effective for the mitigation of age-related muscle loss, as well as for enhanced strength⁽³⁾.
• Whey protein may help reduce inflammation as demonstrated to reduce the inflammatory marker C-reactive protein (CRP)⁽⁴⁾.
• Whey protein may enhance the body’s antioxidant defenses.  In the body, glutathione production depends on the supply of several amino acids, such as cysteine, which is sometimes of limited supply. For this reason, high cysteine foods, such as whey protein, may boost the body’s natural antioxidant defenses⁽²⁾.

L-Citrulline (6g/Scoop)

• What it is: L-Citrulline is an amino acid known by sports researchers to promote exercise endurance and muscle pumps.

• What it does: L-Citrulline significantly increases the rate of ammonia removal (a byproduct of exercise), allowing for increased exercise endurance & increases nitric oxide production.

Main features of L-citrulline

• L-citrulline is effective for improving exercise and athletic performance.
• Supplementing your body with L-citrulline increases arginine, thus increasing nitric oxide levels. Higher nitric oxide levels may lead to increased blood flow, which means your tissues receive more oxygen and nutrients.
• L-citrulline can help increase oxygen uptake and muscle oxygenation.
• Supplementation significantly enhanced cycling performance.
• Supplementation showed that subjective feelings of muscle fatigue, and concentration, right after exercise were significantly improved with L-citrulline⁽⁵⁾.
• L-citrulline helps in the process of making nitric oxide. Nitric oxide causes the blood vessels to expand. This can help lower your blood pressure⁽⁶⁾.

Fig: Changes in plasma NOx before and after a 4 km Time Trial(5).

Fig: Completion times of the 4 km Time Trial after placebo or L-citrulline supplementation(5).

L-Glutamine (4g/Scoop)

• What it is: An amino acid highly prevalent in our digestive, immune, and neurological systems.
• What it does: Regulates digestive normality, supports a healthy immune system, provides glutamate for necessary central nervous system functionality.

Main features of glutamine

Glutamine is an important amino acid with many functions in the body. Glutamine plays a crucial role in immune function. However, during illness or injury, the body may not be able to produce enough of it.

Glutamine supplements improve immune function and preserve protein stores in the body. Your intestines are a major part of your immune system.

Glutamine is an energy source for intestinal and immune cells. It also helps maintain the barrier between the intestines and the rest of your body and aids with proper growth of intestinal cells.

Evidence also indicates that glutamine supplements may decrease muscle soreness and improve recovery after intense exercise⁽⁷⁾. (See figure below.)

Glycerol (3g/scoop)

• What it is: A compound with positive influence on hydration and osmolality of the blood.
• What it does: Reduces thermal burden, leading to increased muscular endurance during exercise. Also influential for cell volume, hyperhydration, and nutrient transportation.

Glycerol or glycerin is a colorless, odorless, viscous liquid that is sweet-tasting and mostly non-toxic. It is widely used in the food industry as a sweetener and humectant and in pharmaceutical formulations.

Glycerol is an important component of triglycerides (i.e. fats and oils) and phospholipids. Glycerol is a three-carbon substance that forms the backbone of fatty acids in fats. When the body uses stored fat as a source of energy, glycerol and fatty acids are released into the bloodstream. The glycerol component can be converted into glucose by the liver and provides energy for cellular metabolism. Normally, glycerol shows very little acute toxicity and very high oral doses, or acute exposures can be tolerated.

Mechanism of action: Glycerol accumulates in body fluids, except those found in the eyes and brain, increasing osmotic pressure and the total volume of water in the body. It can also be used as an energy substrate, and if consumed in large enough quantities, could contribute to the energy yield during training.

When glycerol is consumed orally, as in the case of sports supplements, it’s rapidly absorbed by the body and distributed between fluid compartments before being metabolized by the liver and kidneys.

If it’s consumed along with a hefty amount of fluid, osmotic pressure increases which helps your body retain that large volume of fluid and leads to the expansion of various fluid spaces in the body. This creates a state of “hyperhydration”, which is of great benefit to hard-training athletes, particularly endurance athletes⁽¹⁾.

Betaine Anhydrous (2.5g/scoop)

• What it is: A form of trimethylglycine, often found in foods such as beets.
• What it does: Modulates homocysteine levels in the blood, leading to higher cardiovascular efficiency. Promotes higher rates of creatine synthesis. Enhances muscular endurance during exercise. Acts as an osmolyte, contributing to sustained hydration during exercise.

Betaine anhydrous is a chemical that occurs naturally in the body and can also be found in foods such as beets, spinach, cereals, seafood, and wine. A form of betaine called betaine anhydrous helps in the metabolism of homocysteine, a chemical involved in the normal function of many different parts of the body, including blood, bones, eyes, heart, nerves, and the brain.

Betaine anhydrous prevents the buildup of homocysteine seen in people who have problems with its metabolism from birth.

The charts below show how betaine affected various metrics:

Creatine Monohydrate (2.5g/scoop)

• What it is: A compound often found in food sources such as red meat, with well-established performance benefits.
• What it does: Helps to regenerate ATP, which cells use for energy. Enhances muscular strength, muscle volumization, and power output. Assists in neurological health.

Importance of creatine metabolism in whole-body physiology. The creatine/phosphocreatine system is essential for the chemo-mechanical energy transduction of cells/tissues with high, fluctuant, and constant energy demands.

 Creatine’s direct role in ATP production means it can drastically improve high-intensity exercise performance⁽⁹⁾.

Creatine improves numerous factors, including:

• Strength
• Ballistic power
• Sprint ability
• Muscle endurance
• Resistance to fatigue
• Muscle mass
• Recovery
• Brain performance

Unlike supplements that have been shown to primarily impact advanced athletes, creatine has been shown to provide benefits regardless of a person’s fitness level⁽¹⁰⁾.

Creatine has therapeutic applications beyond athletic performance

Creatine, a well-established ergogenic aid in sports, is now being investigated for its potential therapeutic applications in various medical domains, including neuropsychiatric disorders, heart failure, etc.

Current and “forward-looking” insights

Mental health: Recent evidence suggests that creatine supplementation may exert antidepressant effects by enhancing brain energy metabolism and modulating neurotransmitter systems. Some studies suggest it may have potential as an adjunctive treatment for major depressive disorder, particularly in cases resistant to a single therapy.

Stroke Management: In preclinical models, creatine has demonstrated neuroprotective properties, including the reduction of infarct size and the preservation of mitochondrial function during ischemic events (i.e., an event in which an organ or body part is not getting enough blood/oxygen). preclinical findings to date suggest that creatine could be used to mitigate occurrence and damage of ischemic events, by stabilizing ATP levels and lowering oxidative damage.

Heart Failure: Heart failure is characterized by a mismatch between ATP supply and demand in cells of the heart. Creatine's role in the Cr/PCr/ATP shuttle offers a targeted approach to restoring cellular energetics in failing cells. Although clinical studies present mixed results, the mechanistic rationale supports further investigation into creatine as a complementary therapy in heart failure management.

Beta Alanine: 2g/scoop

• What it is: A compound used in the body to create carnosine (often produces a harmless tingling sensation in the skin known as paresthesia).
• What it does: Increases carnosine concentration. Helps buffer an exercise-caused compound called lactic acid, allowing for sustained rates of muscular output & fatigue prevention.

Beta-alanine is a non-essential amino acid.  Unlike most amino acids, it is not used by your body to synthesize proteins.  Instead, together with histidine, it produces carnosine.

Carnosine is then stored in your skeletal muscles. Carnosine reduces lactic acid accumulation in your muscles during exercise, which leads to improved athletic performance. In your muscles, histidine levels are normally high and beta-alanine levels low, which limits the production of carnosine.  Supplementing with beta-alanine has been shown to elevate carnosine levels in muscles by 80%⁽¹¹⁾.

This is how carnosine acts during exercise:

• Glucose is broken down: Glycolysis is the breakdown of glucose, which is the main source of fuel during high-intensity exercise.
• Lactate is produced: As you exercise, your muscles break glucose down into lactic acid. This is converted into lactate, which produces hydrogen ions (H+).
• Muscles become more acidic: The hydrogen ions reduce the pH level in your muscles, making them more acidic.
• Fatigue sets in: Muscle acidity blocks glucose breakdown and reduces your muscles' ability to contract. This causes fatigue.
• Carnosine buffer: Carnosine serves as a buffer against the acid, reducing the acidity in muscles during high-intensity exercise.

Since beta-alanine supplements increase carnosine levels, they help your muscles reduce their acid levels during exercise. This lessens overall fatigue⁽¹¹⁾.

Red Spinach Leaf Extract (1g/scoop)

• What it is: Concentrated red spinach leaves, with a higher concentration of betacyanins, and naturally occurring nitrates.
• What it does: Exhibits anti-inflammatory benefits within the body, leading to lower rates of inflammation during exercise. Contributes to enhanced blood flow and muscular pumps⁽¹²⁾.

Health Benefits of Red Spinach

Red spinach is a superfood that is bursting with nutrients and powerful antioxidants and is fantastic for your overall health and well-being.

Here are some of the health benefits explained in detail:

1. Rich in nutrients: Red spinach is a nutritional powerhouse, packed with vitamins, minerals, and dietary fibers that nourish the body and contribute to overall health.

2. Antioxidant properties: The vibrant red color indicates the presence of anthocyanins, powerful antioxidants that neutralize harmful free radicals, protecting the body from oxidative stress and reducing the risk of chronic diseases⁽¹³⁾.

3. Heart health: Red spinach has a high potassium content which helps regulate blood pressure, while its nitrate content promotes healthy blood flow, supporting cardiovascular health⁽¹⁴⁾.

4. Eye health: The presence of lutein and zeaxanthin in red spinach promotes eye health by protecting against age-related macular degeneration and cataracts.

5. Digestive health: Rich in dietary fibers, red spinach aids in digestion, prevents constipation, and promotes a healthy gut environment.

6. Bone health: Abundant in calcium and magnesium, red spinach contributes to strong bones and may help prevent osteoporosis.

7. Immune system support: Red spinach contains vitamins A and C, as well as other antioxidants, which bolster the immune system and helps the body fend off infections and illnesses.

8. Anti-inflammatory effects: The antioxidants and phytochemicals in red spinach possess anti-inflammatory properties, which may help reduce inflammation in the body.

9. Weight management: Low in calories and high in fiber, red spinach can aid in weight management by promoting satiety and supporting a balanced diet.

10. Detoxification: The nutrients in red spinach aid in the body’s natural detoxification processes, supporting liver function and eliminating toxins, which contributes to overall well-being .

Agmatine Sulfate (750mg/scoop)

• What it is: A derivative of the amino acid L-Arginine.
• What it does: Contributes to higher rates of blood flow via vasodilation. Modulates neurotransmitter activity. May reduce physical & cognitive stress.

Agmatine is a compound naturally formed from the amino acid L-arginine. It is a neurotransmitter found predominantly in neurons. Because it can target multiple receptors, researchers are investigating it in the context of a wide spectrum of complex diseases. Furthermore, some research suggests that agmatine may play a role in cognitive function, stress resiliency, mood, and athletic performance.

Mechanisms of action: Agmatine is a natural component of the inner workings of many cells, and as such, it has complex interactions with cellular function. Researchers have been working to untangle agmatine’s mechanisms and effects by studying human and animal cells as well as bacteria⁽¹⁵⁾.

Agmatine appears to block the production of NOS (nitric oxide synthase).  Thus, some researchers believe agmatine may regulate nitric oxide levels⁽¹⁵⁾.

N.O.7 (400mg/scoop)

• What it is: STEEL’s exclusive pump-enhancement & endurance formulation.
• What it does: Enhances blood flow. Contributes to significant muscular pumps. Increases cardiovascular endurance.

Punica granatum

Punica granatum L. (Punicaceae) is the fruit with the highest phytoestrogen concentrations, which contains significant amounts of phenolic antioxidant.

The use of punica granatum has beneficial effects contributing to:

• Reduction in systolic blood pressure
• Increase in the endothelium-dependent relaxation in coronary arteries
• Reduction in oxidative stress
• Inhibition of eNOS phosphorylation at its inhibitory residue Thr495
• Improve in lipid profile.

Taken together, these effects can protect against the development and/or progression of coronary vascular diseases. Most of these effects may be related, at least in part, with estrogenic actions of phytoestrogens.  

Punica granatum was used to analyze the functionality of the endothelium. The treatment significantly increased vasodilator response when compared to their respective control group (see figure below)

(-) Epicatechin

(-) Epicatechin is the most abundant flavanol found in and absorbed from dark chocolate, and is thought to exhibit health-promoting biological activity. 

Additionally, (–)-epicatechin was demonstrated to be the only catechin stereoisomer capable of inducing vasodilation of the femoral artery upon direct infusion into the bloodstream. 

Results from human trials indicate that (–)-epicatechin elicits beneficial effects on the vascular system. Acute administration of 200 mg of (–)-epicatechin resulted in the augmentation of nitric oxide production and reduced endothelin-1, a marker of oxidative stress, in healthy men. Similar results were reported for nitric oxide production in healthy males after ingestion of (–)-epicatechin-rich cocoa⁽¹⁶⁾.

Icariin

Icariin is a chemical compound classified as a prenylated flavonol glycoside, a type of flavonoid.  

It is thought that icariin is an active component of Epimedium extracts, as it has been shown to share several mechanisms of action with compounds used in Western medicine to treat impotence.

In particular, icariin is a weak PDE5 inhibitor in vitro and enhances the production of nitric oxide⁽¹⁷⁾.

VasoDrive-AP (254mg/scoop)

• What it is: Tripeptides (Valyl-Prolyl-Proline & Isoleucyl-Prolyl-Proline) derived from milk protein.
• What it does: Acts as a vasodilator, allowing for enhanced rates of blood flow and contributes to muscular pumps.

One of the most researched tripeptide ingredients for cardiovascular health, VasoDrive-AP (also known as AmealPeptide^®) is said to improve arterial flexibility by increasing the production of endothelial nitric oxide synthase (eNOS).

Derived from milk protein through a proprietary enzymatic process, VasoDrive-AP occurs in very small amounts in casein as tripeptides, which are three specific amino acids joined together in a precise configuration. It works to support arterial elasticity by inhibiting an enzyme that leads to the constriction of blood vessels.

The two tripeptides in VasoDrive-AP are known as the lactotripeptides Valyl-Prolyl-Proline (VPP) and Isoleucyl- Prolyl-Proline (IPP); they are derived from the amino acids valine, proline, and isoleucine.

It is manufactured by enzymatically hydrolyzing casein in a precise manner with the protease derived from Aspergillus oryzae in such a way that the peptides are not damaged or broken down into their individual amino acids. They are also not degraded in the human digestive system because of their precise configuration and can be absorbed intact to be physiologically active.

These lactotripeptide combinations are not found in high enough quantities in common foods (such as dairy) to be sufficiently healthful.

Supported by more than 30 published studies — including over a dozen double-blind, placebo-controlled human clinical trials — VasoDrive-AP (Amealpeptide) promotes arterial elasticity.

VasoDrive-AP also boosts exercise performance by improving recovery and sustaining endothelial function throughout training cycles⁽¹⁸⁾.

Research shows that VasoDrive-AP supplementation can⁽¹⁸⁾:

• Improve arterial flexibility by potentiating the production of eNOS
• Support healthy glucose utilization
• Improve recovery and sustain endothelial function throughout training cycles
• Reduce muscle soreness after high-intensity exercise
• Reduce mild exercise-related fatigue
• Long-term solution for optimal intra-workout pump as well as post-workout recovery

Fig. NO biosynthesis from L-arginine by eNOS promotes vasodilation by activating guanylate cyclase to form cGMP that, in turn, decreases Ca2+ within smooth muscle cells, diminishing vascular tone and leading to vasodilation(18).

elevATP^® (75mg/scoop)

• What it is: Ancient Peat & Apple Polyphenols.
• What it does: Clinically shown to increase levels of endogenous adenosine triphosphate (ATP), the energy currency of the body, and support improved strength, power, and performance in resistance-trained athletes.

Scientific Studies on elevATP^®

As one of the more innovative new ingredients on the market, elevATP^® has been investigated in several clinical trials.

Study 1

20 healthy adults supplemented with 150 mg of elevATP^® in a single-dose crossover clinical trial. The subjects had their blood work measured prior to supplementation, 60 minutes after, and 120 minutes after. The researchers noted that supplementation with elevATP^® increased whole blood levels of ATP by 40% after 60 minutes⁽¹⁹⁾.

Fig: Effect of elevATP® on blood ATP levels. elevATP® significantly increased blood ATP levels by 40% at T60 and T120

Study 2

The effects of supplementing 150 mg of elevATP^® on step exercise performance was evaluated in a three-way crossover trial. The subjects that supplemented with elevATP^® saw an increase in exercise performance, whole blood ATP levels, and caloric burn compared to placebo⁽²⁰⁾.

Fig: Total steps taken during exercise. Subjects supplemented with elevATP® Lot A or elevATP® Lot B took more steps than the same subjects taking placebo(20).

Fig: Total calories burned during 20 min of exercise. Subjects supplemented with elevATP® Lot A or elevATP® Lot B burned more calories than the same subjects taking placebo(20)

Study 3

The effects on body composition when subjects supplemented with 150 mg daily of elevATP^® in combination with a 12-week resistance training program was evaluated. The subjects that supplemented with elevATP^® saw increased muscle cross sectional area and muscle thickness. The researchers concluded that elevATP^® supplementation may enhance the hypertrophy (muscle-building) effects of resistance training⁽²¹⁾.

Fig: Changes in muscle thickness. Delta values between corresponding weeks are presented as means ± SD. *, Significantly different from placebo (PLA). TRT, ancient peat and apple extracts(21).

Study 4

The effects on athletic performance when subjects supplemented with 150 mg daily of elevATP^® in combination with a 12-week resistance training program was evaluated. The subjects that supplemented with elevATP^® saw increased levels of lower body strength, lower body power, and total strength. The researchers concluded that elevATP^® may augment the body’s strength and power adaptations to resistance training⁽²²⁾.

Squat 1RM increased to a greater extent in proprietary blend of ancient peat and apple extract (TRT) than placebo (PLA) from week 8 to weeks 10 and 12; deadlift increased to a greater extent in TRT than PLA from week 8 to week 12; and total strength increased in TRT versus PLA from week 8 to week 12 (see figure below)

Fig: Changes in Total Strength. Delta values between corresponding weeks are presented as mean ± standard deviation(22).

Vertical jump peak power significantly (p < 0.05) increased in TRT from week 8 to weeks 10 and 12 (Fig. 2), and vertical jump peak velocity increased from weeks 8 to 10, while PLA experienced decrements in both variables at these time points (see figure below)

Fig: Changes in Vertical Jump Peak Power. Delta values between corresponding weeks are presented as mean ± standard deviation(22).

Study 5

The effects on body composition when subjects supplemented with a combination of 150 mg daily of elevATP^®, 180 mg of extended-release caffeine, and B-vitamins while following a 12-week resistance training program was evaluated. The subjects that supplemented with this blend saw increased levels of muscle hypertrophy⁽²³⁾.

Fig: Changes in cross sectional area (CSA). Delta values between corresponding weeks are presented as mean ± standard deviation. * indicates significantly different from placebo(23).

Gymnema Sylvestre Extract (67mg/scoop)

• What it is: Concentrated form of Gymnema, standardized to 75% gymnemic acids.
• What it does: Assists in modulating blood sugar levels, whilst providing antioxidant properties.

Gymnema Sylvestre Leaf Extract 75% (providing 50.25 mg of gymnemic acids): Gymnema sylvestre is a woody climbing shrub that’s native to the tropical forests of India, Africa and Australia.  Gymnemic acids in Gymnema sylvestre can block the sugar receptors on your tongue, decreasing your ability to taste sweetness. This can lead to reduced sugar cravings.  

Gymnema sylvestre has anti-diabetic properties and may lower your blood sugar levels after a meal. Gymnema sylvestre appears to contribute to favorable insulin levels by increasing insulin production and regenerating insulin-secreting islet cells. Both can help lower blood sugar levels⁽²⁴⁾.

AstraGin (50mg/scoop)

• What it is: Astragalus root & Panax notoginseng.
• What it does: Increases Nutrient and Amino Acid absorption, while maintaining gut-wall integrity.

Benefits may include⁽²⁵⁾:

• Reduction in markers of inflammation in the gut: Improving cellular function and in turn nutrient absorption.
• Increases in nutrient transporter enzymes: Directly aiding in nutrient absorption efficiency.
• Increased immune system function: Increasing the 'alertness' of immune system markers.
• Improved Gut Health: Reported improvements in good bacteria and inhibition/reduction in bad bacteria.

In summary, this creates and environment for a healthier, better functioning intestinal tract, enhancing overall health but also and importantly for supplements allowing effective delivery of highly dosed ingredients.

R-Alpha Lipoic Acid (50mg/scoop)

• What it is: R-Lipoic Sodium Salt.
• What it does: Supports carbohydrate assimilation, and regulates blood sugar levels.

Alpha-lipoic acid (ALA) is a mitochondrial compound involved in energy metabolism. Alpha-lipoic acid has become popular as a potential aid for diabetes, as it’s been shown to lower blood sugar levels in both animals and humans.  Studies done in adults with metabolic syndrome have shown that it may reduce insulin resistance and lower fasting blood glucose and HbA1c levels. 

Mechanism of action: It helps lower blood sugar by promoting processes that can remove fat that has accumulated in muscle cells, which otherwise make insulin less effective. Moreover, alpha-lipoic acid may lower the risk of diabetes complications⁽²⁶⁾.

It’s proven to ease symptoms of nerve damage and lower the risk of diabetic retinopathy (eye damage) that can occur with poorly controlled diabetes. This mechanism of action is due to the powerful antioxidant properties of alpha-lipoic acid⁽²⁶⁾.

Coenzyme Q10 (CoQ10) (50mg/scoop)

• What it is: A compound found in the body, vital for energy production within the mitochondria of the cell.”
• What it does: Acts as a potent antioxidant, provides cardiovascular + respiratory functionality, and is a crucial component in the cellular respiration process.

Antioxidant Effects

CoQ10 in its ubiquinol form is a strong antioxidant that protects the cell and mitochondrial membranes. But even in its oxidized form as ubiquinone, it may still have some antioxidant effect. The membrane that surrounds cells contains fats that help keep it stable. These fats can become oxidized and damaged, which causes the cell to not work as well.

CoQ10 is found within the cell membrane where it acts to prevent this oxidative damage.

CoQ10 is carried around the bloodstream by lipoproteins such as LDL and HDL. LDL is especially prone to becoming oxidized; where it then becomes more dangerous than regular LDL and may trigger plaque formation and hardening of the arteries. CoQ10 helps prevent LDL from becoming oxidized.

CoQ10 is recognized as a powerful antioxidant that demonstrates protective effects against a spectrum of diseases, including diabetes and associated cardiovascular complications. Current research suggests that CoQ10 operates through mechanisms that include the reduction of oxidative stress, anti-inflammatory actions, and the regulation of glucose and lipid metabolism. By modulating the Nrf2/Keap1/ARE pathway, CoQ10 can ameliorate diabetes-induced oxidative stress and subsequently stimulate the production of antioxidant enzymes.

Given the close association between T2DM and oxidative damage, the involvement of the Nrf2/Keap1/ARE pathway in addressing this unresolved clinical issue has become a topic of significant interest. It is now evident that dysfunction of this pivotal antioxidant pathway plays a central role in the pathogenesis of diabetes and its diverse complications⁽²⁸⁾.

Fig: The Nrf2/Keap1/ARE pathway has a role in a wide range of tissues(28).

Evidence indicates the potential of CoQ10 in enhancing various physiological aspects in the context of diabetes. CoQ10 treatment led to a notable increase in Nrf2 expression and catalase activity within the liver tissue, accompanied by a significant reduction in malondialdehyde levels and considerable improvements in the lipid profile.

These results indicate that the antioxidative effects of CoQ10 in diabetes might be attributed to the activation of the Nrf2/ARE pathway⁽²⁹⁾.

Ginger Root Extract (5mg/scoop)

• What it is: Concentrated ginger root.
• What it does: In small amounts, ginger root extract may assist in easing digestive discomfort.

• Gingerol and gingerol-related compounds: These compounds have Antioxidant and antitumor properties inducing apoptosis and genetic modulation, anti-inflammatory and analgesic effects, and antimicrobial and hepatoprotective properties.
• Zingerone: This compound exhibits antioxidant, anti-inflammatory, and antibacterial properties.
• Shogaol: This compound demonstrates antioxidant, anti-inflammatory, and anti-cancerous properties by inhibiting cell invasion, decreasing matrix metalloproteinase-9 expression, and increasing anti-proliferation properties.
• Paradol: This compound is known for its antioxidant, anti-cancerous, and antimicrobial properties.
• Zingerone: This compound has antioxidant, anti-inflammatory, and antibacterial properties.
• 1-Dehydro-10-ginger-dione: This compound is involved in the modulation of inflammatory genes.
• Ginger flavonoids: This compound possesses antioxidant activity.
• Terpenoids: This compound induces apoptosis through the activation of p53.

HYPERBOLIC Feature Highlights

Protein Derived Aminos

In HYPERBOLIC, we decided to utilize a clear whey protein isolate as opposed to adding individual amino acids.

The reason we have done this is twofold:

1. As our understanding of exercise science and nutrition evolves, we become more thoughtful about how we are using ingredients to fuel our performance. Individually included amino acids are shown to increase muscle recovery and protein synthesis, but they do not contain comparable caloric usability, and amino acid mixes often do not include the “non-essential” amino acids. This is fine, but not as useful for the body as it could be, because the way we absorb the majority of our nutrients is through the breakdown and assimilation of food (which contains calories). Whey protein isolate is a complete protein source, and absorbing all of the amino acids found within the protein, the body uses them with a higher rate of efficiency. This means higher rates of effectiveness for muscle protein synthesis, muscular recovery, and contributes towards your overall protein goals for the day.
2. Protein refinement processes have made it feasible to include protein within a peri-workout formulation. Whey protein, given its nature, has a creamy and thick texture/taste profile, which often conflicts with the flavoring system and other active ingredients in pre and intra formulas. However, clear whey protein isolate undergoes additional microfiltration to remove lactose, carbohydrates, and fats, and can be easily flavored in ways that pre and intra workout users are more familiar with: that being juicy and fruit-based flavors.

Strength and Endurance

HYPERBOLIC includes a dedicated suite of strength-augmenting compounds like 5g creatine monohydrate, 5g betaine anhydrous and 2g beta alanine, to recruit more reps, sets, output, and muscular endurance from your workout. These ingredients saturate your muscles with water, electrolytes, and nutrients in order to facilitate long-lasting effects that lead to overall higher rates of muscle recruitment and muscle recovery.

Performance-Minded Electrolytes

We have included a suite of electrolytes within HYPERBOLIC, to sustain athletic performance as rates of sweat increase throughout a workout. Because a wide variety of individuals will be consuming this product, we have carefully aligned the electrolytes to provide the end user with sufficient hydration, prevent muscle cramps, promote digestive ease, and promote recovery.

Daily Creatine Supply

One scoop of HYPERBOLIC contains 2.5 grams of creatine monohydrate, a dose modular enough to provide you with the benefits of creatine without interfering with other creatine monohydrate supplements. If HYPERBOLIC is your sole source of supplementary creatine, 2 scoops provides 5 grams, which is a universally accepted dosage for daily supplementation.

Along with being one of the most studied sports nutrition ingredients on the planet, creatine monohydrate has been proven to increase strength levels, provide intramuscular hydration, and even support cognitive function. Creatine monohydrate works synergistically with other ingredients including our electrolyte suite and glycerol to ensure that hydration levels are maximized throughout a workout.

Nutrient Assimilation & Expedited Recovery Signaling

We utilize the same ingredients found in ADA-LOAD that are dedicated to the assimilation of the ingredients found within HYPERBOLIC, while supporting ideal blood pressure and blood sugar levels. The increased rates of nutrient uptake allow HYPERBOLIC to further push its anabolism-inducing profile, while providing a foundation for heightened rates of recovery and significant muscle pumps.

Nutrient uptake during or immediately after a workout has been shown to reduce recovery times. HYPERBOLIC leverages heightened levels of nutrient assimilation, calorically viable complete protein content, and a variety of recovery-focused compounds to reduce muscle soreness, enhance muscle recovery, provide full-body hydration, and promote more consistent performance over time.

Full Body Cellular Energy

While being stimulant-free, HYPERBOLIC provides full-body cellular energy through mitochondrial efficiency, and rapid ATP replenishment.

CoQ10 establishes a positive effect on the electron chain transport. This works in tandem with other ingredients such as elevATP^® and creatine monohydrate to ensure that cellular health and ATP recycling is at their highest rates possible, allowing for sustained performance and strength output.

Elite Nitric Oxide Production

HYPERBOLIC provides an all-encompassing nitric oxide and pump enhancement profile, consisting of 8 of the most effective ingredient for their respective roles: L-Citrulline, Glycerol, Betaine Anhydrous, Creatine Monohydrate, Red Spinach Leaf Extract, Agmatine Sulfate, N.O.7, and VasoDrive-AP.

• L-Citrulline: Ammonia removal via urea cycle, eNOS pathway vasodilation, nitric oxide increase
• Glycerol: Osmolyte activity, thermal burden reduction, muscular endurance, muscle saturation
• Betaine Anhydrous: Osmolyte activity, homocysteine modulation, muscular stamina
• Creatine Monohydrate: Muscle hydration, muscle saturation, ATP replenishment
• Red Spinach Leaf Extract: Nitric oxide production, blood flow, anti-inflammatory
• Agmatine Sulfate: NOS inhibition, nitric oxide production, blood flow
• N.O.7: Blood flow, PDE5 inhibition, femoral arterial dilation
• Vasodrive-AP: eNOS production, sustains blood flow, anti-inflammatory

HYPERBOLIC FAQ’s

Q: How Do I Take HYPERBOLIC?
It can be taken pre workout, intra workout, and post workout. Mix 1 scoop with 16-20oz of water. Take up to 1 scoop pre-workout. An additional scoop may be taken intra or post workout. For maximum assimilation do not exceed 1 scoop per hour. Do not exceed 2 scoops per day. Start with 1 scoop to assess your tolerance.

Q: Does HYPERBOLIC Contain Caffeine?
No, HYPERBOLIC does not contain any caffeine.

Q: Can Women Take HYPERBOLIC?
Yes! HYPERBOLIC can be taken by men and women. Please refer to the Suggested Body Weight Guide and directions to determine an appropriate dosage.

Q: Can I take other STEEL products with HYPERBOLIC?
Yes. HYPERBOLIC does not contain any stimulants, so it can be stacked with other STEEL products that do. Due to the potency of HYPERBOLIC, stimulant products such as PRE, CHARGED, and AMPED-AF are more commonly stacked with HYPERBOLIC.

Q: Do I Really Need 16-20 OZ of water per scoop of HYPERBOLIC?
Yes. HYPERBOLIC utilizes and relies on sufficient water and hydration to facilitate its highest potential. Using less water than recommended may impede the maximum effectiveness of HYPERBOLIC, or cause the user to feel dehydrated. We highly recommend sticking to the directions when it comes to HYPERBOLIC. 

Q: How is HYPERBOLIC different from ADABOLIC?
ADABOLIC is dosed to provide performance benefits to a wide range of athletes, and is well-suited for those focusing on weight loss, or weight gain. HYPERBOLIC is specifically formulated to provide optimal benefits to individuals looking to put on size, and maintain as much anabolism as possible pre, intra, and post workout.

Q: How is HYPERBOLIC different from HYPERADE?
HYPERADE is primarily composed of a specialized carbohydrate called ClusterDextrin, which allows for carb-based athletic performance and endurance. HYPERBOLIC consists of over 40 different compounds with a heavy emphasis of  maximizing performance and recovery from activities such as weightlifting, bodybuilding, strongman, and similar styles of training.

Q: Can HYPERBOLIC and ADABOLIC be taken together?
Yes. Both HYPERBOLIC and ADABOLIC are formulated to work synergistically. Please see Directions on each product to determine the appropriate dosage and water amount.

If you want to get the most out of every rep and maximize your muscle building potential, consider adding HYPERBOLIC to your daily training routine.

HYPERBOLIC is specifically formulated for individuals looking to put on size, and maintain as much anabolism as possible pre, intra, and post workout.  

HYPERBOLIC consists of over 40 different compounds with a heavy emphasis of maximizing performance and recovery from activities such as weightlifting, bodybuilding, strongman, and similar styles of training. It's the pros' secret weapon!

References:
    1.    Patlar S, Yalçin H, Boyali E: The effect of glycerol supplements on aerobic and anaerobic performance of athletes and sedentary subjects. J Hum Kinet 34:69-79, 2012
    2.    Kimball SR, Jefferson LS: Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr 136:227s-31s, 2006
    3.    Paddon-Jones D, Rasmussen BB: Dietary protein recommendations and the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care 12:86-90, 2009
    4.    Zhou LM, Xu JY, Rao CP, et al: Effect of whey supplementation on circulating C-reactive protein: a meta-analysis of randomized controlled trials. Nutrients 7:1131-43, 2015
    5.    Suzuki T, Morita M, Kobayashi Y, et al: Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study. J Int Soc Sports Nutr 13:6, 2016
    6.    Barkhidarian B, Khorshidi M, Shab-Bidar S, et al: Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis. Avicenna J Phytomed 9:10-20, 2019
    7.    Legault Z, Bagnall N, Kimmerly DS: The Influence of Oral L-Glutamine Supplementation on Muscle Strength Recovery and Soreness Following Unilateral Knee Extension Eccentric Exercise. Int J Sport Nutr Exerc Metab 25:417-26, 2015
    8.    Cholewa JM, Wyszczelska-Rokiel M, Glowacki R, et al: Effects of betaine on body composition, performance, and homocysteine thiolactone. J Int Soc Sports Nutr 10:39, 2013
    9.    Buford TW, Kreider RB, Stout JR, et al: International Society of Sports Nutrition position stand: creatine supplementation and exercise. J Int Soc Sports Nutr 4:6, 2007
    10.    Willoughby DS, Rosene J: Effects of oral creatine and resistance training on myosin heavy chain expression. Med Sci Sports Exerc 33:1674-81, 2001
    11.    Hobson RM, Saunders B, Ball G, et al: Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino Acids 43:25-37, 2012
    12.    Gonzalez AM, Accetta MR, Spitz RW, et al: Red Spinach Extract Supplementation Improves Cycle Time Trial Performance in Recreationally Active Men and Women. J Strength Cond Res 35:2541-2545, 2021
    13.    Al-Temimi AA, Al-Hilifi SA, Al-Mossawi AE: An investigation on glutathione derived from spinach and red cabbage leaves and their effects of adding to meat patties. Saudi J Biol Sci 30:103632, 2023
    14.    Haun CT, Kephart WC, Holland AM, et al: Differential vascular reactivity responses acutely following ingestion of a nitrate rich red spinach extract. Eur J Appl Physiol 116:2267-2279, 2016
    15.    Mun CH, Lee WT, Park KA, et al: Regulation of endothelial nitric oxide synthase by agmatine after transient global cerebral ischemia in rat brain. Anat Cell Biol 43:230-40, 2010
    16.    Ottaviani JI, Momma TY, Heiss C, et al: The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo. Free Radic Biol Med 50:237-44, 2011
    17.    Ning H, Xin ZC, Lin G, et al: Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology 68:1350-4, 2006
    18.    da Silva DVT, Baião DDS, Almeida CC, et al: A Critical Review on Vasoactive Nutrients for the Management of Endothelial Dysfunction and Arterial Stiffness in Individuals under Cardiovascular Risk. Nutrients 15, 2023
    19.    T. Reyes-Izquierdo CS, R. Argumedo1, B. Nemzer, Z. Pietrzkowski: THE EFFECT OF ELEVATP™ ON WHOLE BLOOD ATP LEVELS: A SINGLE DOSE, CROSSOVER CLINICAL STUDY. Journal of Aging Research & Clinical Practice 1:1-5, 2014
    20.    Tania Reyes-Izquierdo BN, Ruby Argumedo, Melissa Cervantes and Zbigniew Pietrzkowski: The Effect of ElevATP™ on Exercise Output: A Single Dose, Blinded, Three-Way
Cross-Over Study. Current Trends in Nutraceuticals 1, 2016
    21.    Joy JM, Falcone PH, Vogel RM, et al: Supplementation with a proprietary blend of ancient peat and apple extract may improve body composition without affecting hematology in resistance-trained men. Appl Physiol Nutr Metab 40:1171-7, 2015
    22.    Joy JM, Vogel RM, Moon JR, et al: Ancient peat and apple extracts supplementation may improve strength and power adaptations in resistance trained men. BMC Complement Altern Med 16:224, 2016
    23.    Joy JM, Vogel RM, Moon JR, et al: Twelve weeks supplementation with an extended-release caffeine and ATP-enhancing supplement may improve body composition without affecting hematology in resistance-trained men. J Int Soc Sports Nutr 13:25, 2016
    24.    Forouhar E, Sack P: Non-traditional therapies for diabetes: fact or fiction. J Community Hosp Intern Med Perspect 2, 2012
    25.    Turck D, Castenmiller J, De Henauw S, et al: Safety of a botanical extract derived from Panax notoginseng and Astragalus membranaceus (AstraGin™) as a novel food pursuant to Regulation (EU) 2015/2283. Efsa j 18:e06099, 2020
    26.    Kim YS, Kim M, Choi MY, et al: Alpha-lipoic acid reduces retinal cell death in diabetic mice. Biochem Biophys Res Commun 503:1307-1314, 2018
    27.    Cordero MD, Cano-García FJ, Alcocer-Gómez E, et al: Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀ effect on clinical improvement. PLoS One 7:e35677, 2012
    28.    Tsai KL, Huang YH, Kao CL, et al: A novel mechanism of coenzyme Q10 protects against human endothelial cells from oxidative stress-induced injury by modulating NO-related pathways. J Nutr Biochem 23:458-68, 2012
    29.    Modi MMK: Ginger Root. StatPearls [Internet], 2024