February 11, 2020 5 min read

Game-changing (adj): Completely changing the way something is done, thought about or made.

 

When it comes to your health, muscle endurance, and muscle building strength, having healthy and robust blood flow is the key to all your progress.

That's why it’s important to not only have a strong and healthy heart, but also strong and flexible veins and arteries to help your blood flow more efficiently. 

N.O.7 is the most advanced nitric oxide booster designed to be the quickest and most effective way to get maximum pumps with the very first use, no loading phase, and no waiting.

It's the perfect stimulant-free addition to your pre-workout that will provide skin-splitting pumps, increased vasodilation, and maximum nitric oxide production while you're at the gym.

N.O.7 is backed by science to help optimize:

  • Cell volumization
  • Endurance
  • Increased blood flow
  • Enhance muscle pump

Here is an ingredient breakdown of this incredible nitric oxide booster:

N.O.7 Blend: SurePumpTM: Punica granatum, (-) Epicatechin, 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,4S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one

SurePump™ is an ingredient blend of 3 different natural plant extracts in a specific ratio that includes polyphenols and nitrates to increase blood flow and blood vessel diameter.

Each ingredient has plenty of human studies backing up what they do, which increases vasodilation via different mechanisms of action.

  • One ingredient works via the eNOS pathway, like arginine and citrulline.
  • Another works on endothelial relaxation, which increases blood, oxygen, and nutrient flow and blood vessel diameter.
  • The last ingredient works as a phosphodiesterase 5(PDE5) inhibitor which increases the production of Nitric Oxide naturally by increasing cGMP which causes vasodilation.

Prescription PDE5 inhibitors are commonly used for erectile dysfunction because of this mechanism. Together in the right ratio, SurePump™ maximizes vasodilation and Nitric Oxide production to give you the ultimate pump in the gym. 

 

Punica granatum: Punica granatum L. (Punicaceae) is the fruit with the highest phytoestrogen concentrations, which contains significant amounts of phenolic antioxidants. The use of Punica granatum has beneficial effects contributing to:

  • Reduction in systolic blood pressure
  • Increase in the endothelium-dependent relaxation in coronary arteries
  • Reduction in oxidative stress
  • Inhibition of eNOS phosphorylation at its inhibitory residue Thr495
  • Improve in lipid profile.

Taken together, these effects can protect against the development and/or progression of coronary vascular diseases. Most of these effects may be related, at least in part, with estrogenic actions of phytoestrogens. 

Punica granatum was used to analyze the functionality of the endothelium. The treatment significantly increased vasodilator response when compared to their respective control group (see figure below)

Figure: Dose-response curves to bradykinin (0,1–1000 ng) in isolated hearts. Sham group (A) and OVX group (B) before (closed symbols) and after (open symbols) perfusion with L-NAME (100 μM) for 20 min. Data were expressed as mean ± SEM; n = 6–10 animals per group.p < 0.05 compared with the vehicle group before L-NAME. #p < 0.05 compared with both groups after L-NAME.

References:

  • Espín J. C., García-Conesa M. T., Tomás-Barberán F. A. (2007). Nutraceuticals: facts and fiction. Phytochemistry 68 2986–3008.
  • Front Pharmacol. 2016; 7: 522.

 

(-) Epicatechin: (–) epicatechin is the most abundant flavanol found in and absorbed from dark chocolate, and is thought to exhibit health-promoting biological activity. 

Additionally, (–)-epicatechin was demonstrated to be the only catechin stereoisomer capable of inducing vasodilation of the femoral artery upon direct infusion into the bloodstream. 

Results from human trials indicate that (–)-epicatechin elicits beneficial effects on the vascular system. Acute administration of 200 mg of (–)-epicatechin resulted in the augmentation of nitric oxide production and reduced endothelin-1, a marker of oxidative stress, in healthy men. Similar results were reported for nitric oxide production in healthy males after ingestion of (–)-epicatechin-rich cocoa.

Figure: Mean (± SEM) plasma endothelin-1 (ET-1) concentrations before (□) and 2 h after (▪) (A) and mean (± SEM)

 

Figure: Proof-of-concept: Vascular response after oral ingestion of (–)-epicatechin. (A and C) FMD (A) and PAT (C) index significantly increased 2 h after ingestion of 1 or 2 mg/kg epicatechin in water (filled columns) but not water alone (open column; n = 3; cross-over). (B and D) Time course of FMD (B) and PAT (D) index after ingestion of water (open circles) or 1 mg/kg (–)-epicatechin in water (n = 3). Data represent means ± SEM. *, P < 0.05 vs. baseline at 0 h of respective day; #, P < 0.05 vs. respective time point on control day

References:

  • Ottaviani JI, Momma TY, Heiss C, Kwik-Uribe C, Schroeter H, Keen CL. The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo. Free Radic Biol Med. (2011
  • Schwarz et al Front. Nutr., 21 December 2018
  • Loke WM, Hodgson JM, Proudfoot JM, McKinley AJ, Puddey IB, Croft KD. Pure dietary flavonoids quercetin and (–)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men. Am J Clin Nutr. (2008) 88:1018–25
  • Hagen Schroeter, Christian Heiss, Jan Balzer, Petra Kleinbongard, Carl L. Keen, Norman K. Hollenberg, Helmut Sies, Catherine Kwik-Uribe, Harold H. Schmitz, and Malte Kelm (–)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. PNAS January 24, 2006 103 (4) 1024-1029;

 

5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,4S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one: Icariin is a chemical compound classified as a prenylated flavonol glycoside, a type of flavonoid. 

It is thought that icariin is an active component of Epimedium extracts, as it has been shown to share several mechanisms of action with compounds used in Western medicine to treat impotence. In particular, icariin is a weak PDE5 inhibitor in vitro and enhances the production of nitric oxide.

Figure: Inhibition of PDE5 isoforms by icariin and zaprinast. Purified PDE5A1, PDE5A2, or PDE5A3 protein was incubated with 15,000 counts per minute of [3H]cGMP in presence of varying amounts of icariin or zaprinast. All assays were performed in triplicate. (A) Inhibition of PDE5A1 by icariin or zaprinast. (B) Inhibition of PDE5A2 by icariin or zaprinast. (C) Inhibition of PDE5A3 by icariin or zaprinast. (D) Inhibition of PDE5 isoforms by zaprinast. (E) Inhibition of PDE5 isoforms by icariin.

Figure: Expression of eNOS mRNA in EA. hy926 cells treated with icariin (10 μmol l−1) and 50 μmol l−1 quercetin for different time at 5 min, 6 h, 12 h,24 h, 48 h, 72 h. The ethidium bromide-stained gels of PCR products were analyzed by computer-assisted densitometry and the data were plotted for eNOS genes in relation to β-actin gene expression. Similar data were obtained in three independent RT-PCR experiments.Pb0.05,⁎⁎Pb0.01 vs. control group (n= 3).

References:

  • Ning H, Xin ZC, Lin G, Banie L, Lue TF, Lin CS (2006). "Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells". Urology. 68 (6): 1350–4.
  • Xu HB, Huang ZQ (2007). "Icariin enhances endothelial nitric-oxide synthase expression on human endothelial cells in vitro". Vascul. Pharmacol.

No matter how you train, whether it's lifting weights, yoga, running, walking, boxing, HIIT, or CrossFit, healthy and robust blood flow is the key to it all. 

N.O.7 is here and the intense pumps you have been chasing are just one cap away...

Dr. Paul Henning, PhD

About Dr. Paul

I'm currently an Army officer on active duty with over 15 years of experience and also run my own health and wellness business. The majority of my career in the military has focused on enhancing Warfighter health and performance. I am passionate about helping people enhance all aspects of their lives through health and wellness. Learn more about me