May 15, 2020 10 min read
Coenzyme Q10 (CoQ10) is an important compound found in every cell in the body. It is a type of coenzyme, which means that it helps enzymes work more effectively. CoQ10 is mainly located in the membrane of mitochondria, where it is used to make energy.
This new formulation significantly enhances coenzyme Q-10 bioavailability and maintains its efficacy on the cellular level.
Backed by Science to Help Optimize:
• HEART HEALTH*
• METABOLISM SUPPORT*
• HEALTH & WELL-BEING*
• ENERGY PRODUCTION IN HEART AND MUSCLES*
CoQ10 is an essential compound that helps your body fight disease and damage on a cellular level, and it's a key contributor to heart, lung, and reproductive health…
and CoQ10 now you can support your body's cellular health and maximize protection from oxidative damage with the optimal delivery system that is CoQ10 Liposomal.
Here are the ingredients that can help optimize your cellular health:
Coenzyme Q-10 w/ Cyclosome® Technology: Coenzyme Q10 (CoQ10) is a crucial compound found in every cell in the body and its main function is to help enzymes work more efficiently. CoQ10 is mainly located in the membrane of mitochondria, where it is used to make energy.
CoQ10 helps shuttle electrons in the mitochondria to produce ATP, the main form of cellular energy. It is also found in cell membranes and in lipoproteins – such as LDL and HDL – where it acts as a powerful antioxidant. CoQ10 stabilizes cell membranes, helping cells work properly.
Energy-demanding organs in your body have the highest levels of CoQ10. These organs include the brain, heart, kidneys, muscle, and liver – all of which contain many mitochondria and use a lot of energy. Many different diseases and conditions, as well as nutrient deficiencies, can reduce the body’s capacity to make CoQ10 or cause CoQ10 to be depleted faster than it can be replaced. In these cases, supplementation may be helpful or necessary.
CoQ10 is commonly supplemented to help improve diseases that involve mitochondrial dysfunction and increased oxidative stress such as fibromyalgia, chronic fatigue syndrome, and diabetes. Supplementation may also be beneficial for heart diseases, including heart failure.
Some people also take CoQ10 supplements to combat the side effects of statins. Athletes, on the other hand, use them to enhance performance.
CoQ10, in its ubiquinol form, is a strong antioxidant that protects the cell and mitochondrial membranes. But even in its oxidized form as ubiquinone, it may still have some antioxidant effect. The membrane that surrounds cells contains fats that help keep it stable. These fats can become oxidized and damaged, which causes the cell to not work as well. CoQ10 is found within the cell membrane where it acts to prevent this oxidative damage.
Fig: Coenzyme Q10 levels, catalase levels and lipid peroxidation (MDA levels) in blood mononuclear cells (BMCs) from fibromyalgia (FM) patients and healthy control individuals.(A) CoQ10 levels were measured by HPLC, as described in Materials and Methods. (B) Catalase was analyzed in BMCs as described in Materials and Methods. (C) LPO was measured as described in Material and Methods. (D) ATP levels were analyzed in BMCs as described in Materials and Methods. Data represent the mean ± SD of three separate experiments Ref: PLoS One. 2012; 7(4): e35677.
CoQ10 is carried around the bloodstream by lipoproteins such as LDL and HDL. LDL is especially prone to becoming oxidized; where it then becomes more dangerous than regular LDL and may trigger plaque formation and hardening of the arteries. CoQ10 helps prevent LDL from becoming oxidized.
Fig: The protective effects of CoQ10 on oxLDL-mediated ROS generation in HUVECs. After preincubation for 2 h with the indicated concentrations of CoQ10 (2.5–20μM), HUVECswere incubated with the H2O2-sensitive fluorescent probe DCF-AM (10μM) for 1 h, followed by treatment with 130μg/ml oxLDL or nLDL for 2 h. (A) Fluorescence images exhibited theROS level in control cells (left) and HUVECs stimulated with oxLDL (middle) in the presence of 10μM CoQ10 (right). (B) Fluorescence intensity of HUVECs was measured with afluorescence microplate reader. Fluorescence distribution of DCF-AM oxidation was expressed as a percentage of increased intensity. The activityof (C) SOD and (D) catalase inHUVECs stimulated with oxLDL in the absence or presence of indicated concentrations of CoQ10 were determined. Data are expressed as the mean±S.E. of three independent analyses.#Pb.05 vs. untreated control;⁎Pb.05 compared with oxLDL treatment.462K.-L. Tsai et al. / Journal of Nutritional Biochemistry 23 (2012) 458–468 Ref: J Nutr Biochem. 2012 May;23(5):458-68
During recent years, science is accomplishing huge advances in drug discovery through modeling and synthesis toward the treatment of idiopathic diseases. However, even if promising molecules are identified and synthesized, its effectiveness will be reduced or equal to zero if they are unable to achieve the therapeutic target because of poor absorption. Approximately 90% of the developed molecules on investigation are chemically lipophilic (i.e. tending to combine with or dissolve in lipids or fats) drugs or, in other words, insoluble drugs in water and unable to cross physiological barriers on oral administration.
To enhance drug bioavailability of lipophilic actives, liposomal technology of encapsulation, which is a lipid spherical structure that allows the insoluble active substances in water to get intertwined with the forming phospholipids of the membrane, while hydrophilic (i.e. having a tendency to mix with, dissolve in water) actives can also be encapsulated in its aqueous core. Among many other benefits, this has converted them in an extensively used and very versatile drug delivery technology. This technology has been tested utilizing state of the art high-performance liquid chromatography (HPLC) and shown to be extremely effective in absorbing more of the compound.
Fig: A high-performance liquid chromatography (HPLC) method was developed to simultaneously quantify three widely used active substances such as coenzyme Q10, phosphatidylserine, and vitamin C. This new method optimizes current timing and costs in the analyses of these three active substances. Additionally, since the analyzed compounds were encapsulated on a cutting-edge liposomal formulation, further processing was necessary to be developed prior to HPLC analyses. The technique was studied and adequately validated in accordance with the guidelines of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) regarding selectivity, linearity, accuracy, precision, and robustness. After data treatment of results, linear regressions for all active substances showed an optimal linearity with a correlation coefficient of >0.999 in the concentration range between 70 to 130% of the liposomal formulation and less than a 3% relative standard deviation (RSD) in accuracy and precision. Ref: ACS Omega. 2019 Nov 11;4(22):19710-19715
Cyclosome® Technology with Phospholipids:
NON-GMO Soy Lecithin: Lecithin is a food additive that comes from several sources — one of them being soy. It’s generally used as an emulsifier, or lubricant, when added to food, but also has uses as an antioxidant and flavor protector. Some of the benefits of lecithin include:
The most well-known benefit of lecithin is its ability to lower cholesterol. Scientists discovered that soybean lecithin can contribute to raising HDL (good) cholesterol and lowering LDL (bad) cholesterol in blood profiles.
Soy protein provides an extra boost for people using it to treat cholesterol because of other components that soy offers.
Improves heart health
Lecithin that comes from soy can improve cardiovascular health, especially if you’re already at risk of developing high blood pressure or heart disease. This is according to a small study in which participants were given soy products including lecithin additives.
Helps improve digestion
Lecithin has been tested in people with ulcerative colitis to improve their digestion. Lecithin’s emulsifying qualities contribute to a chain reaction that improves the mucus in your intestine, making the digestive process easier and protecting the delicate lining of your digestive system.
Even if you do not have ulcerative colitis, you might want to consider using lecithin if you have irritable bowel syndrome or another condition that affects your digestive process.
Phosphatidylcholine:Phosphatidylcholine is a phospholipid attached to a choline particle. Phospholipids contain fatty acids, glycerol, and phosphorous.
Lecithin is the phosphorous part of the phospholipid substance and is made up of phosphatidylcholine. Foods that contain lecithin are the best dietary sources of phosphatidylcholine.
Although phosphatidylcholine is traditionally used to support brain health, it can also support liver function and keep cholesterol levels in check. Below are some key evidence-based benefits of this nutritional supplement.
It can help boost cognitive function
According to a 1995 study on mice with dementia, phosphatidylcholine supplementation can increase the neurotransmitter acetylcholine in the brain. It may also improve memory. The study found that mice without dementia had no memory increase, despite the increase in acetylcholine levels.
A 2001 study found feeding mice a diet rich in phosphatidylcholine and vitamin B-12 also had a positive impact on brain health.
Research has continued, and a 2017 study has found that levels of phosphatidylcholine are directly related to Alzheimer’s disease.
It may aid in liver repair
A high-fat diet is known to negatively affect the liver. It may cause nonalcoholic fatty liver disease or cirrhosis of the liver. According to a 2010 study, phosphatidylcholine helped reduce lipids that can lead to a fatty liver (hepatic lipids) in mice fed a high-fat diet.
Another study on mice reviewed whether bringing elevated levels of phosphatidylcholine back to normal helps prevent nonalcoholic fatty liver disease. The study found that it helped prevent the accumulation of fat in the liver. It did not, however, prevent nonalcoholic fatty liver disease.
It may help ease symptoms of ulcerative colitis
Ulcerative colitis causes inflammation in the digestive tract. It may also cause ulcers. According to a 2010 study, people with ulcerative colitis often have reduced levels of phosphatidylcholine in their intestinal mucus. Supplementation may help protect the mucus layer of the digestive tract and reduce inflammation.
It may promote lipolysis
Lipolysis is the breakdown of fats in the body. Too much fat may cause lipomas to form. Lipomas are painful, benign fatty tumors. Most are removed surgically.
According to a 2014 study, injecting phosphatidylcholine into a lipoma can kill its fat cells and reduce its size.
Lysophosphatidylcholine: Lysophosphatidylcholine (LPC) is a major plasma lipid constituent that is produced from phosphatidylcholine (PC). The results of a recent study confirmed the importance of lysophosphatidylcholine in the lipid absorption process and showed that it facilitates efficient intestinal lipid transport by accelerating lipid absorption. This aidsthe absorption and enhancement of vitamin C bioavailability
Phosphatidylethanolamine: Phosphatidylethanolamine is a multifunctional phospholipid required for mammalian development that is essential for a variety of cellular processes.
Phosphatidylethanolamine is a non-bilayer forming phospholipid containing a small polar head group diameter in proportion to its fatty-acid chains.
As a polar head group, phosphatidylethanolamine creates a more viscous lipid membrane compared to phosphatidylcholine. This essentially aids in the absorption ofvitamin C in new types of liposomes; thus enhancing vitamin C bioavailability
Hydroxypropyl-B cyclodextrin(HPBCD): Cyclodextrins (CDs) are useful formulation vehicles, which increase the amount of drug that can be solubilized in aqueous vehicles, thus increasing delivery of many useful medicinal agents to a biological system.
Without a successful delivery system, many drugs could not be developed. 2-hydroxylpropyl-β-cyclodextrin (HP-β-CD), a hydroxyalkyl derivative, is an alternative to α-, β- and γ-cyclodextrin, with improved water-solubility properties.
Phytosterol 90% Complex: Phytosterols, or plant sterols, are a family of molecules related to cholesterol. They are found in the cell membranes of plants, where they play important roles — just like cholesterol in humans.
The most common phytosterols in your diet are campesterol, sitosterol, and stigmasterol. Plant stanols — another compound occurring in your diet — are similar.
It is a well-documented fact that phytosterols can lower cholesterol levels. Eating 2–3 grams of phytosterols per day for 3–4 weeks can reduce “bad” LDL cholesterol by around 10%.
This is particularly effective for people who have high cholesterol — whether or not they’re taking cholesterol-lowering statin drugs. Phytosterol is believed to work by competing for the same enzymes as cholesterol in your gut, effectively preventing cholesterol from being absorbed.
Microcrystalline Cellulose: Microcrystalline cellulose (C6H10O5)n is refined wood pulp. It is a white, free-flowing powder. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. In large quantities it provides dietary bulk and may lead to a laxative effect. Microcrystalline cellulose is a commonly used excipient in the pharmaceutical industry. It has excellent compressibility properties and is used in solid dose forms, such as tablets. Tablets can be formed that are hard, but dissolve quickly. Microcrystalline cellulose is the same as cellulose, except that it meets USP standards.
Colloidal Silica Anhydrous: Silica, colloidal anhydrous is a porous and granular form of silicon dioxide that is synthetically made from sodium silicate. It is used as a free-flow agent to assist powder flow, e.g. in tableting, by reducing the angle of repose of bulk powder. Surfactant – used for flocculating, coagulating, dispersing, stabilizing, etc. Liquid silicon dioxide (colloidal silica) is used as a wine and juice fining agent.
Magnesium Stearate: Magnesium stearate is commonly added to many foods, pharmaceuticals, and cosmetics. In medications and vitamins, its primary purpose is to act as a lubricant.
Magnesium stearate is an additive that’s primarily used in medication capsules. It’s considered a “flow agent.” It’s possible to create medication capsules without magnesium stearate, but it’s more difficult to guarantee the consistency and quality of those capsules.
Magnesium stearate is used to delay breakdown and absorption of medications, so they’re absorbed in the correct area of the bowel.
How it Works in Your Body
During digestion, magnesium stearate dissolves into its component parts: magnesium and stearic acid. Magnesium is an essential mineral and stearic acid is a highly digestible fat found in many foods. An enzyme called stearoyl-CoA desaturase converts stearic acid into oleic acid. Oleic acid is also found in olive oil. It is an important building block of the brain and nervous system.
FD&C Yellow: Yellow 5 is an artificial food color (AFC) that was approved for use in foods in 1969 by the FDATrusted Source. Its purpose to is make foods — particularly highly processed foods like candy, soda, and breakfast cereals — appear more fresh, flavorful, and appetizing.
Yellow 5 is considered an azo compound with the formula C16H9N4Na3O9S2. That means in addition to carbon, hydrogen, and nitrogen — typically found in natural food dyes — it also includes sodium, oxygen, and sulfur. These are all naturally occurring elements.
If you're looking to optimize your cellular health there may be no better way than with a daily dose of CoQ10.
You can learn more about it here.