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April 24, 2024 8 min read

Morosil blood orange extract has garnered attention lately for its potential role in weight management. Derived from the unique Moro blood orange variety grown in the Mediterranean Basin, Morosil is rich in antioxidants and bioactive compounds that may offer benefits for those looking to shed excess pounds.

This guide explores the science behind Morosil's weight loss properties, how to incorporate it into your diet, and what to consider before adding it to your weight loss regimen.

Morosil and its Origins

Sicilian oranges

Morosil is a commercial name for a supplement derived from the juice of a specific variety of Sicilian blood oranges (Citrus sinensis L. Osbeck). Morosil® is made by the Italian company Bionap S.R.L., a group which has produced standardized extracts obtained from Moro blood oranges since 1997

The Moro blood orange variety is believed to have originated in Italy, specifically in the region around Mount Etna in Sicily. It is thought to be a natural mutation of the “Sanguinello” blood orange variety, which is also native to Sicily. The exact origins of the Moro blood orange are not well-documented, but it is believed to have been discovered in the early 19th century.

The unique climate and soil conditions around Mount Etna are thought to contribute to the distinct flavor and color of the Moro blood orange. The volcanic soil, along with the warm days and cool nights in the region, is believed to enhance the development of the anthocyanin pigments that give the Moro blood orange its deep red color.

Today, Moro red oranges are grown not only in Sicily but also in other citrus-growing regions around the world, including San Diego, California. However, the original Moro blood oranges from Sicily are still highly prized for their exceptional flavor and quality.

Morosil is marketed as a weight management supplement due to its high content of anthocyanins, flavones, hydroxycinnamic acids, and ascorbic acid, which are believed to have beneficial effects on metabolism and fat accumulation.

Moro Variety vs. Other Orange Cultivars

Orange cultivars

The Moro blood orange variety stands out from other existing blood orange varieties primarily due to its unique combination of flavor, color, and nutritional content. Here are some key characteristics that distinguish the Moro blood orange:

— Color

Moro blood oranges are known for their deep red to burgundy flesh, which is due to the presence of anthocyanins, a type of antioxidant pigment not typically found in citrus fruits. This gives the Moro oranges a distinctive appearance compared to other blood orange varieties, which may have lighter red or orange flesh.

— Flavor

Moro blood oranges are prized for their rich and complex flavor profile, which is sweeter than that of regular oranges and often has hints of raspberry or berry-like notes. This unique flavor makes them popular for use in juices, cocktails, and culinary dishes.

— Nutritional Content

Moro blood oranges are rich in vitamin C, like other citrus fruits, but they also contain higher levels of flavonoids like anthocyanins, which give Moro blood oranges their deep red flesh. Anthocyanins are antioxidants that have been linked to various health benefits, including reducing inflammation and improving heart health.

— Availability

Moro blood oranges are typically in season from December to April, making them a winter fruit in the Northern Hemisphere. This seasonality adds to their appeal and makes them a sought-after specialty fruit in many markets.

Overall, the Moro blood orange's unique combination of color, flavor, and nutritional content sets it apart from other blood orange varieties and makes it a popular choice for fitness enthusiasts and others who find weight management important.


Research and clinical studies on ways to reduce the prevalence of obesity is ongoing. Reportedly, more than 70% of adults in the U.S. are overweight or obese.

Not all types of body fat pose the same risks. Certain types, such as abdominal fat, pose the most significant threat. Therefore, aspects like body composition and fat distribution play significant roles.

In a randomized, placebo-controlled study, 60 overweight adults were administered either a placebo or 400 mg of Morosil juice daily for a duration of 12 weeks. Compared with the placebo group, the Morosil group experienced statistically significant reductions in average body weight, body mass index (BMI), waist circumference and hip circumference. Furthermore, follow-up observations indicated positive weight maintenance.

According to the results of this study, published in January 2022, the researchers concluded that the active compounds contained in Moro juice have a synergistic effect on fat accumulation in humans and Moro juice extract can bring about a significant decrease in fat mass. It can also be used in weight management and in the prevention of human obesity.

Another group of researchers performed clinical tests on mice, which were later tested on humans, to evaluate the effect of Moro orange juice on gene expression of lipid transcription factors and metabolic enzymes. The data obtained showed that Moro juice administration was able not only to limit weight gain but also to decrease serum triglycerides and total cholesterol, and improve liver steatosis – a condition caused by obesity. Results revealed Moro juice exerted a metabolic hepatoprotective effect due to changes in the expression of several enzymes involved in lipid homeostasis.

How Does Morosil Work in the Body?

Blood orange for weight loss

Morosil is often promoted as a weight management supplement, and its purported mechanism of action is related to its high content of bioactive compounds, particularly anthocyanins and flavonoids. However, it's significant to note that the specific mechanisms of Morosil's action in the body are not fully understood and are still the subject of ongoing research.

Some proposed mechanisms by which Morosil may work in the body include:

  • Anti-obesity effects: Anthocyanins and flavonoids found in Morosil are believed to have anti-obesity effects. These compounds may help regulate lipid metabolism, reduce the accumulation of fat in adipose tissue, and inhibit adipogenesis, the formation of new fat cells.

  • Antioxidant activity: Morosil's high antioxidant content may help reduce oxidative stress and inflammation, which are associated with obesity and metabolic disorders. By reducing oxidative stress, Morosil may help improve metabolic function and support weight management.

  • Regulation of lipid metabolism: Some studies suggest that Morosil may help regulate lipid metabolism by modulating gene expression factors that would otherwise promote fat storage and accumulation.

  • Blood sugar regulation: Morosil may also help regulate blood sugar levels, which is important for managing weight and reducing the risk of metabolic disorders like diabetes. This effect may be due to its antioxidant and anti-inflammatory properties.

  • Heart health: Morosil enriched blood orange extract contains biophenols that may be used for weight control and, acting on fat accumulation, it can indirectly be used to promote healthy cardiovascular functions.

It's important to note that while some studies suggest potential benefits of Morosil for weight management, more research is needed to fully understand its mechanisms of action and confirm its effectiveness. As with any supplement, it's always advisable to consult a healthcare professional before starting Morosil or any other dietary supplement.

How is Morosil Extract Made?

Blood orange juice concentrate

The process of making Moro blood orange extract for supplements involves several steps to extract and concentrate the beneficial compounds from Moro blood oranges.

Here is a general overview of the process used for producing a standardized extract:

  1. Harvesting: Moro blood oranges are harvested when they are ripe and at their peak flavor and nutrient content. The oranges are typically hand-picked to ensure quality.

  2. Juicing: The oranges are washed and then juiced to extract the juice from the fruit. This juice contains bioactive compounds, including anthocyanins and flavonoids, that are believed to have health benefits.

  3. Filtration: The juice is then filtered to remove any pulp or solid particles, leaving behind a clear liquid.

  4. Concentration: The filtered juice is concentrated to increase the concentration of the bioactive compounds. This can be done through various methods, such as evaporation or membrane filtration.

  5. Drying: The concentrated juice may be further processed to remove water and create a powdered extract. This can be done through methods like spray drying, where the juice is sprayed into a hot chamber to remove moisture and create a powder.

  6. Standardization: The final Morosil extract may be standardized to ensure that each batch contains a consistent amount of bioactive compounds. This helps ensure the effectiveness and quality of the supplement.

  7. Encapsulation: The Morosil extract may then be encapsulated into capsules or tablets for easy consumption as a dietary supplement.

Blood Orange Extract Capsules

It's important to note that the exact process of making Morosil extract may vary depending on the manufacturer and the specific product. Additionally, the effectiveness of the extract may depend on factors such as the quality of the oranges used and the extraction method employed.

How to Include Morosil for Weight Management in a Diet?

Including Morosil in your diet for weight management can be done in several ways.

Here are some suggestions:

1. Morosil Supplements

If you prefer not to consume Morosil in its natural form, you can find Morosil Extract supplements in the form of capsules, tablets, powders, and even gummies. These supplements can be taken according to the manufacturer's instructions.

2. Morosil Juice

Freshly squeezed Morosil blood orange juice can be a refreshing and healthy addition to your diet. You can drink it on its own or mix it with other juices or water for a flavorful beverage.

Blood orange juice

3. Morosil Smoothies

Blend Morosil juice with other fruits, vegetables, and protein sources like yogurt or protein powder to create a nutritious and filling smoothie. This can be a great option for a meal replacement or a healthy snack.

4. Morosil Zest

The zest of Morosil oranges can be used to add flavor to various dishes, including salads, marinades, and desserts. The zest contains essential oils that can enhance the flavor of your food without adding extra calories.

5. Morosil in Recipes

Incorporate Morosil juice or zest into your favorite recipes to add a citrusy flavor. For example, you can use Morosil juice as a marinade for chicken or fish, or add Morosil zest to baked goods like cakes and muffins.

It's important to remember that while Morosil Extract may have potential benefits for weight management, it should be used as part of a balanced diet and healthy lifestyle. Consult a healthcare provider or nutritionist before making any significant changes to your diet or taking any new supplements.

Risks and Side Effects of Morosil Extract Supplements

Morosil is generally considered safe for most people when taken at recommended doses. However, as with any supplement, there are potential risks and side effects to be aware of.

Some possible risks and side effects of taking Morosil for weight management may include:

  1. Allergic reactions: Some individuals may be allergic to citrus fruits, including Morosil. Allergic reactions can range from mild symptoms like itching and hives to more severe reactions like swelling and difficulty breathing. If you have a known allergy to citrus fruits, you should avoid taking Morosil supplements.

  2. Gastrointestinal issues: Some people may experience gastrointestinal side effects such as stomach upset, diarrhea, or bloating when taking Morosil. These side effects are usually mild and temporary.

  3. Heartburn: Some individuals may experience gastrointestinal side effects such as heartburn, especially if taken in high doses or on an empty stomach. It may be an issue if you suffer from acid reflux diseases.

  4. Drug interactions: Morosil may interact with certain medications, including blood thinners and medications for high blood pressure. If you are taking any medications, it's important to consult your healthcare provider before starting Morosil to avoid potential interactions.

  5. Effectiveness and safety: While some studies suggest that Morosil may have potential benefits for weight management, more research and clinical trials are needed to fully understand its effectiveness and long-term safety. It's important to use Morosil as part of a comprehensive weight management plan that includes a healthy diet and regular exercise.

Blood orange supplements


Morosil blood orange extract shows promise as a natural supplement for weight management. Its high antioxidant content and unique bioactive compounds set it apart as a potential aid in achieving a healthy weight and maintaining wellness. However, more research is needed to fully understand its effects and mechanisms of action.

As with any supplement, it's essential to consult a healthcare provider before adding Morosil to your diet, especially if you have underlying health conditions or are taking medications. Incorporating Morosil into a balanced diet and active lifestyle may offer additional support for your weight loss journey.